Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-12-11
1988-11-29
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3702
Patent
active
047881798
ABSTRACT:
A method of treating patients suffering from amyotrophic lateral sclerosis (ALS) by administering dipeptide derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups ##STR2## wherein if Z is a group (a), R.sub.2 and R.sub.3 together represent an additional bond between the carbon atoms bearing R.sub.2 and R.sub.3, or if Z is a group (b), R.sub.2 is hydrogen; R.sub.4 and R.sub.5 are hydrogen or lower alkyl, or R.sub.5 may also be phenyl; and R.sub.6 is hydrogen or methyl; hydrates or pharmaceutically acceptable acid additions salts thereof. Pharmaceutical compositions containing effective ALS symptom counteracting amounts of such dipeptide derivatives may be administered by infusion, injection, orally, rectally or percutaneously.
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Barth Hans
Flohe Leopold
Brown J. R.
Gruenenthal GmbH
Moezie F. T.
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