Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-04-29
1996-07-23
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514453, 514468, 514510, 514691, 514729, 514739, 514766, A01N 4316, A01N 4342, A61K 3147
Patent
active
055389830
ABSTRACT:
Various first messengers linked to phospholipase C, including acetylcholine and interleukin-1, regulate the production both of the secreted form of the amyloid protein precursor and of amyloid .beta.-protein. Intracellular signals which are responsible for mediating these effects have now been identified, and that activation of phospholipase C may affect APP processing by either of two pathways, one involving an increase in protein kinase C and the other an increase in cytoplasmic calcium levels. The effects of calcium on APP processing appear to be independent of protein kinase C activation. The observed effects of calcium on APP processing are of therapeutic utility in the treatment of Alzheimer-type amyloidosis.
REFERENCES:
patent: 5242932 (1993-09-01), Gandy et al.
patent: 5270165 (1993-12-01), Van Nostrand et al.
patent: 5276059 (1994-01-01), Caughey et al.
Mattson et al., "Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examples.sup.a ", Annals New York Academy of Sciences, 1-21.
Peterson et al., "Changes in Calcium Homeostasis during Aging and Alzheimer's Disease.sup.a ", Annals New York Academy of Sciences, 262-270.
Buxbaum et al., "Cholinergic Agonists and Interleukin 1 Regulate Processing and Secretion of the Alzheimer B/A4 Amyloid Protein Precursor", Proc. Natl Acad. Sci. USA, 89:10075-10078 (1992).
Khachaturian, Zaven S., "Introduction and Overview", Annals New York Academy of Sciences, 1-4.
Landfield et al., "Mechanisms of Neuronal Death in Brain Aging and Alzheimer's Disease: Role of Endocrine-Mediated Calcium Dyshomeostasis", Journal of Neurobiology, 23:1247-1260 (1992).
Landfield et al., "Phosphate/Calcium Alterations in the First Stages of Alzheimer's Disease: Implications for Etiology and Pathogenesis", Journal of the Neurological Sciences, 106:221-229 (1991).
Le Quan Sang et al., "Platelet Cystolic Free-Calcium Concentration is Increased in Aging and Alzheimer's Disease", Biol. Psychiatry, 33:391-393 (1993).
Botstein et al., "Construction of a Genetic Linkage Map in Man Using Restriction Fragment Length Polymorphisms", Am. J. Hum. Genet., 32, pp. 314-331 (1980).
Buxbaum et al., "Processing of Alzheimer B/A4 amyloid precursor protein: Modulation by agents that regulate protein phosyphorylation" Proc. Natl. Acad. Sci. U.S.A., 87, pp. 6003-6006 (1990).
Cole et al., "Evidence for Lysosomal Processing of Amyloid .beta.-Protein Precursor in Cultured Cells", Neurochem. Res., 14, pp. 933-939 (1989).
Cotran et al., "Robbin's Pathologic Basis of Disease", 4th ed. WB Saunders, Philadelphia (1984).
Glenner and Wong, "Alzheimer's Disease: Initial Report for the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein", Biochem Biophys. Res. Commun., 120 pp. 885-890 (1984).
Glenner and Wong, "Alzheimer's Disease and Down's Syndrome sharing of a Unique Cerebrovascular Amyloid Fibril Protein", Biochem Biophys. Res. Commun., 122, pp. 1131-1135 (1984).
Goldgaber et al., "Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease", Science, 235, pp. 887-880 (1987).
Jenkins, et al. "Fine Mapping of an Alzheimer Disease-Associated Gene Encoding Beta-Amyloid Protein", Biochem. Biophys. Res. Commun., 151 pp. 1-8 (1988).
Kang et al., "The precursor of Alzheimer's Disease amyloid A4 protein resembles a cell-surface receptor", Nature (London), 325, pp. 733-736 (1987).
Masters et al. "Amyloid plaque core protein in Alzheimer disease and Down syndrome", Proc. Natl. Acad. Sci., U.S.A., 82, pp. 4245-4249 (1985).
Palmert et al., ".beta.-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid", Proc. Natl. Acad. Sci. U.S.A., 86, pp. 6338-6342 (1989).
Rosea et al., "Genetic Linkage Studies in Alzheimer's Disease (AD)", Neurology, 38, pp. 173 (1988).
St. George-Hyslop et al. "The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21", Science, 235, 885-890 (1987).
Schellenberg et al., "Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease", Science, 241, pp. 1507-1510 (1988).
Tanzi et al., "The Amyloid .beta. Protein Gene Is Not Duplicated in Brains from Patients with Alzheimer's Disease", Science, 328, pp. 156-157 (1987).
Tanzi et al., "Amyloid .beta. Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Newar the Alzheimer Locus", Science, 235, pp. 880-885, (1987).
Van Broeckhoven et al., "Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families", Nature, 328, pp. 153-155 (1987).
Vitek et al., "Absence of mutation in the .beta.-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer's Disease", Mol. Brain Res., 4, pp. 121-131 (1988).
Weidemann et al., "Identification, Biogenesis, and Localization of Precursors of Alzheimer's Disease A4 Amyloid Protein", Cell, 57, pp. 115-126 (1989).
Zain et al., "Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: Coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex", Proc. Natl. Acad. Sci., U.S.A., 85, pp. 929-933, (1988).
Braun, "Klink, Diagnostik and Therapil der Amyloidosen", Med. Klin., 67, pp. 1271-1274 (1972).
Caporaso et al., "Chloroquine inhibits intracellular degradation but not secretion of Alzheimer .beta./A4 amyloid precursor protein", Proc. Natl. Acad. Sci., 89, pp. 2252-2256 (1992).
Siman et al., ".beta.-Amyloid Precursor is a PEST Protein", Biochem. Biophys. Res. Comm., 165, pp. 1299-1304 (1989).
J. L. Biedler et al., "Morphology and Growth, Tumorigenicity, and Cytogenetics of Human Neuroblasma Cells in Cintinuous Culture", Cancer Res., 33, pp. 2643-2652.
Caporaso et al., "Chloroquine Inhibits Intracellular Degradation But Not Secretion of Alzheimer .beta./A4 Amtloid Precursor Protein", Proc. Natl. Acad. Sci. U.S.A., 87, pp. 2252-2256 (Mar. 15, 1992).
Crandall et al., "Inverse Diffusion Methods for Data Peak Separation", Anal. Biochem., 167, pp. 15 (1987).
Donnelly, R. J. et al., "Interleukin-1 Stimulates the Beta-Amyloid Precursor Protein Promoter", Cell Mol. Neurobiol., 10, pp. 485-495, (1990).
Glenner and Wong, "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein", Biochem Biophys. Res. Commun., 120, pp. 885-890 (1984).
Glenner and Wong, "Alzheimer's Disease and Down's Syndrome sharing of a Unique Cerebrovascular Amyloid Fibril Protein", Biochem Biophys. Res. Commun., 122, pp. 1131-1135 (1984).
Gardella, et al., "Intact Alzheimer Amyloid Precursor Protein (APP) is present in Platelet Membranes and is Encoded by Platelet mRNA", Biochem. Biophys. Res. Commun., 173, pp. 1292-1298 (1990).
Goldgaber et al., "Interleukin 1 regulates synthesis of amyloid .beta.-protein precursor mRNA in human endothelial cells", Proc. Natl. Acad. Sci. USA., 86, pp. 7606-7610 (1989).
Griffin et al., "Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease", Proc. Natl. Acad. Sci. USA., 86, pp. 7611-7615 (1989).
Harlow et al., Antibodies: A Laboratory Manual (Cold Spring Harbor New York 1988).
Huttner et al., "Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium", Proc. Natl. Acad. Sci. U.S.A., 76, pp. 5402-5406 (1979).
Kang et al., "The precursor of Alzheimer's Disease amyloid A4 protein resembles a cell-surface receptor", Nature (London), 325, pp. 733-736 (1987).
E. A. Jaffe, "Culture of Human Endothelial Cell Derived from Umbilical Veins", J. Clin. Invest., 52, pp. 2745-2746.
La Frauci et al., "Characterization of 5'-End Region and the First Two Exons of the .beta.-Protein Precursor Gene", Biochem. Biophys. Res. Commun., 159, pp. 297-304 (1989).
Manning et al., "Identification in rodents and other species of an mRNA homologous to the human .beta.-amyloid precursor", Brain Res.,427, pp. 293-297 (1988).
Masters et al. "Amyloid plaque core protein in Alzheimer disease and Down syndrome", Proc. Natl. Acad. Sci., U.S.A., 82, pp. 4245-4249 (1985).
Pang et al., "Protein
Buxbaum Joseph D.
Greengard Paul
Nutter Nathan M.
The Rockefeller University
LandOfFree
Method of treating amyloidosis by modulation of calcium does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating amyloidosis by modulation of calcium, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating amyloidosis by modulation of calcium will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-713301