Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2001-11-30
2002-05-14
Henley, III, Raymond (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S264110
Reexamination Certificate
active
06387913
ABSTRACT:
FIELD OF THE INVENTION
The present invention concerns methods and compositions useful for the treatment of airway diseases such as asthma.
BACKGROUND OF THE INVENTION
Asthma is one of the most common diseases in industrialized countries, and in the United states accounts for about 1% of all health care costs (K. Weiss et al.,
New Eng. J. Med
. 326, 862-866 (1992)). An alarming increase in both the prevalence and mortality of asthma over the past decade has been reported (Asthma-United States, 1980-1990, MMWR 41, 733-735 (1992)), and occupational asthma is predicted to be the preeminent occupational lung disease in the near future (M. Chan-Yeung and J. Malo European Resp. J. 7, 346-371 (1994)).
PCT Application WO96/40266 to Nyce (Dec. 19, 1996) describes a method of reducing bronchoconstriction in a subject such as an asthma patient by administering an A
1
or A
3
adenosine receptor antisense oligonucleotide.
PCT Application WO96/40162 to Nyce (Dec. 19, 1996)(see also U.S. Pat. No. 5,994,315) describes a method of treating airway disease in a subject by administering an antisense oligonucleotide, particularly certain adenosine receptor antisense oligonucleotides.
U.S. Pat. No. 5,932,557 to Mustafa et al. concerns adenosine A
1
antisense oligonucleotides in the treatment of alcohol and marijuana-induced psychomotor impairments.
There remains a need for new methods and compositions for the treatment of asthma, as well as other airway diseases.
SUMMARY OF THE INVENTION
A first aspect of the invention is a method of treating an airway disease (including inflammation with and without asthma) such as asthma in a subject in need of such treatment, comprising concurrently administering to the subject an A
3
adenosine receptor antagonist and an A
2B
adenosine receptor antagonist (either separately or in a single molecule or composition having both receptor blocking activities), in an amount effective to treat said disease.
A second aspect of the present invention is a composition useful for treating an airway disease in a subject in need of such treatment, comprising, in a pharmaceutically acceptable carrier, an A
3
adenosine receptor antagonist and an A
2B
adenosine receptor antagonist, together in an amount effective to treat said disease.
Accordingly, it is an object of the present invention to provide a novel method and composition for treating an airway disease. This and other objects are achieved in whole or in part by the present invention.
The foregoing and other objects and aspects of the present invention are explained in greater detail in the specification below.
REFERENCES:
patent: 6117878 (2000-09-01), Linden
Henley III Raymond
Jenkins & Wilson, P.A.
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