Method of treating acid lipase deficiency diseases with an MTP i

Details Method of treating acid lipase deficiency diseases with an MTP i Method of treating acid lipase deficiency diseases with an MTP i

1998-01-10

2000-05-23

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514510, 514824, A61K 31445, A61K 3121

Patent

active

060666536

ABSTRACT:
A method is provided for inhibiting or treating diseases associated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.

REFERENCES:
patent: 4346227 (1982-08-01), Terahara et al.
patent: 5712279 (1998-01-01), Biller et al.
Scriver et al "The Metabolic and Molecular Bases of Inherited Disease", Seventh Edition, vol. II, Chapter 82, "Acid Lipase Deficiency: Wolman Disease and Cholesteryl Ester Storage Disease", pp. 2563-2587, (1995).
Scriver et al "The Metabolic and Molecular Bases of Inherited Disease", Seventh Edition, vol. II, Chapter 85, "Niemann-Pick Disease Type C: A Cellular Cholesterol Lipidosis", pp. 2625-2639, (1995).

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