Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-10-17
1991-04-09
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514288, 514824, A61K 31495, A61K 3150, A61K 3144
Patent
active
050065262
ABSTRACT:
A method for the treatment of conditions associated with atherosclerosis in vertebrate animals, particularly man. A prolactin-inhibiting compound administered to the animal exhibiting the atherosclerotic conditions, in dosage sufficient to decrease the total plasma cholesterol and total triglyceride levels, will over a sufficient period of time suppress atherosclerosis and reduce lipid plaques in the walls of the blood vessels of the animal. Exemplary of prolactin-inhibiting compounds are the ergot-related drugs 2-bromo-alpha-ergocryptine, 6-methyl-8 beta-carbobenzyloxy-aminomethyl-10 alpha-ergoline, 1,6-dimethyl-8 beta-carbobenzyloxy-aminomethyl-10 alpha-ergoline, 8-acylaminoergolenes, ergocornine, 9,10-dihydroergocornine, and D-2-halo-6-alkyl-8-substituted ergolines.
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Cincotta Anthony H.
Martin Donn D.
Meier Albert H.
Friedman Stanley J.
Henley III Raymond J.
Louisiana State University
Proctor Llewellyn A.
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