Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-10-07
1996-09-24
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514408, 514826, 514863, 514886, 514921, 514925, 514926, 514927, A61K 3155, A61K 31495, A61K 3140
Patent
active
055591094
ABSTRACT:
A method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma, inflammation or shock by administering an effective amount of a PAF antagonist of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each --R.sup.5, --CH.dbd.CH--R.sup.5 or --C.tbd.C--R.sup.5 ; R.sup.5 is an unsubstituted or substituted C.sub.6 -C.sub.14 carbocyclic aryl of an aromatic heterocyclic having from 5 to 14 ring atoms, of which from 1 to 5 are hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, the heterocyclic group being unsubstituted or substituted; R.sup.3 is hydrogen, a C.sub.1 -C.sub.6 alkyl, cyano, or --R.sup.5 ; X is oxygen or sulfur; A is a 1,4-piperazin-1,4-diyl or a 1,4-homopiperazin-1,4-diyl; B is a C.sub.1 -C.sub.6 alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R.sup.4 is an unsubstituted or substituted phenyl group.
REFERENCES:
patent: 4788206 (1988-11-01), Guthrie et al.
patent: 4794183 (1988-12-01), Nakamura et al.
patent: 4891363 (1990-01-01), Nakamura et al.
patent: 5068340 (1991-11-01), Nakamura et al.
patent: 5192766 (1993-03-01), Nakamura et al.
patent: 5369106 (1994-11-01), Nakamura et al.
Iijima Yasuteru
Miyamoto Masaaki
Nakamura Norio
Ohkawa Nobuyuki
Oshima Takeshi
Sankko Company, Limited
Weddington Kevin E.
LandOfFree
Method of treating a PAF-mediated pathology or for treating or p does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating a PAF-mediated pathology or for treating or p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating a PAF-mediated pathology or for treating or p will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1928535