Method of transdermally administering high molecular weight drug

Details Method of transdermally administering high molecular weight drug Method of transdermally administering high molecular weight drug

1996-11-12

2000-02-15

Brouillette, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514944, 514946, 424 7015, 424448, A61F 1300

Patent

active

060249757

ABSTRACT:
A high molecular weight drug is transdermally administered by applying a polymer skin enhancer and a drug active to the skin of the patient. The drug active has a molecular weight of above 50 daltons and takes at least 15% by weight of the system. The drug may be encapsulated or the drug solution may be partly encapsulated and partly free. The skin enhancer is polyvinylpyrrolidone (PVP) and it is mixed at between 7 and 35% of the drug. A gelling agent may be optionally added at up to 20% by volume. The chemical system is preferably administered via a multidose transdermal drug patch assembly which includes a drug-impervious support impressed to form a series of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The support is adhesively secured to the skin of a patient. Individual devices are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing devices are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. The drug may also be administered in a creme.

REFERENCES:
patent: 4573996 (1986-03-01), Kwiatek et al.
patent: 4624665 (1986-11-01), Nuwayser
patent: 4666441 (1987-05-01), Andriola et al.
patent: 4952560 (1990-08-01), Kigasawa
patent: 5162043 (1992-11-01), Lew
patent: 5225192 (1993-07-01), Lovrecich
patent: 5232703 (1993-08-01), Blank
patent: 5234957 (1993-08-01), Mantelle
patent: 5252334 (1993-10-01), Chiang et al.
"Controlled-Release Technology" Lee et al., 1986.

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