Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1983-05-02
1985-06-11
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
A01N 3100
Patent
active
045228310
ABSTRACT:
Ovarian follicular development and related hormonal secretions are totally suppressed for periods of several months or longer by a single intramuscular injection of anordrin administered during menstruation given preferably on the first day of menstrual bleeding. The amount of anordrin administered is in the range of 2 to 10 mg per kg of body weight, and is effective to produce the suppression without administration of additional anordrin by any route. Suppression of progesterone and estradiol secretions is of therapeutic value in the treatment of endometrosis, breast cancer, and other conditions aggravated by ovarian hormones.
REFERENCES:
Hodgen, Fertile Steril. (1982) 38:281-300.
Koering, In Animal Models for Research in Contraception and Fertility (1979) pp. 187-199, Edited by Alexander.
Nilsson et al, Fertile Steril. (1982) 37:30-34.
Ku et al, Scientia Sinica, vol. XVIII, No. 2, 262-270 (1975).
Mehta, et al, Steroids, vol. 38, No. 6, pp. 679-691 at 680 (1981); vol. 40, No. 1, 65-80, (1982).
Hu et al, WHO Symposium on Steroid Contraception and Mechanisms of Endometrial Bleeding, E. Diczfalusy et al (eds) Geneva, Sep. 12-14, 1979, pp. 191-200.
Chinese J. Obset. and Gynecol. 3: 85-88 (1978).
Northwestern University
Roberts Elbert L.
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