Method of thrombin inhibition

Details Method of thrombin inhibition Method of thrombin inhibition

1995-06-07

1999-09-21

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, 548535, A61K 3805

Patent

active

059554339

ABSTRACT:
A method of inhibiting thrombin is disclosed, as well as a method of treating or preventing thrombosis and hypercoaguability. The methods employ compounds of the formula ##STR1## stereoisomers thereof and physiologically acceptable salts thereof.

REFERENCES:
patent: 4346078 (1982-08-01), Bajusz et al.
patent: 4568636 (1986-02-01), Svendsen
patent: 5037819 (1991-08-01), Han
patent: 5110812 (1992-05-01), Han
Chemical Abstracts, vol. 99, No. 25, Dec. 19, 1983 (Columbus, Ohio, USA), Bajusz, Sandor et al, "Inhibition of Thrombin with H-and Boc-D-Phe-Pro-Agm," p. 21, Abstract No. 205609.

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