Method of therapy for degenerative intervertebral discs

Details Method of therapy for degenerative intervertebral discs Method of therapy for degenerative intervertebral discs

2011-05-03

2011-05-03

Hui, San-ming (Department: 1628)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

Reexamination Certificate

active

07935337

ABSTRACT:
To treat diseases accompanied by degenerative intervertebral discs, in particular, disk herniation, lumbar pain, discopathy and osteoarthritits of the spine, it is intended to provide a drug for administering a human-origin protease directly to an affected part of such a disease accompanied by degenerative intervertebral discs. As the human-origin protease, use can be made of MMP-3, MMP-7, etc.

REFERENCES:
patent: 1 111 047 (2001-06-01), None
patent: 4-506003 (1992-10-01), None
patent: 10-080283 (1998-03-01), None
patent: 10099084 (1998-04-01), None
patent: 11169176 (1999-06-01), None
patent: 2000-139480 (2000-05-01), None
patent: WO 90/13561 (1990-11-01), None
patent: WO 97/40157 (1997-10-01), None
Avakyan, “Effect of the Proteolytic Enzymes Trypsin and Chymopsin on an Intervertebral Disk Under Experimental Conditions,”Chem. Abstr. 78:23, Abstract No. 106601b (1973).
Benoist et al., “Chemonucleolysis in the Treatment of Sciatica from Herniated Lumbar Disc,”La Nouvelle Presse Médicale11(28):2121-2124 (1982).
Buttle, “Chemonucleolysis: An Example of Therapeutic Tissue Damage,”Research Monographs in Cell and Tissue Physiology15:269-278 (1988).
Einarson et al., “Chymopapain,”Drug Intelligence and Clinical Pharmacy18:560-568 (1984).
Haro et al., “The Role of MMP in Intervertebral Disc Tissues—From Disc Degeneration to Herniated Disc,”Rheumatism41(1):44-50 (2001).
Haro et al., “The Role of MMPs in the Resorption Process of Herniated Disc,”Connective Tissue33:51-57 (2001).
Haro et al., “Matrix Metalloproteinase-3—Dependent Generation of a Macrophage Chemoattractant in a Model of Herniated Disc Resorption,”The Journal of Clinical Investigation105(2): 133-141 (2000).
Haro et al., “Matrix Metalloproteinase-7—Dependent Release of Tumor Necrosis Factor-α in a Model of Herniated Disc Resorption,”The Journal of Clinical Investigation105(2):143-150 (2000).
Haro et al., “Up-Regulated Expression of Matrilysin and Neutrophil Collagenase in Human Herniated Discs,”Journal of Spinal Disorders12(3):245-249 (1999).
Haro et al., “Chemonucleolysis With Human Stromelysin-1,”Spine22(10):1098-1104 (1997).
Haro et al., “Upregulated Expression of Chemokines in Herniated Nucleus Pulposus Resorption,”Spine21(14):1647-1652 (1996).
Herron et al., “Does the MMPI Predict Chemonucleolysis Outcome?”Spine13(1):84-88 (1988).
Kudo et al., “Experimental Chemonucleolysis with Chymopapain in Canine Intervertebral Disks,”J. Vet. Med. Sci.55(2):211-215 (1993).
Roberts et al., “Matrix Metalloproteinases and Aggrecanase: Their Role in Disorders of the Human Intervertebral Disc,”Spine25(23):3005-3013 (2000).
Sagona et al., “Pretreatment Serum Levels of IgE to Chymopapain in Reactive Patients,”Annals of Allergy55:674-677 (1985).
Troisier et al., “The Treatment of Lumbosciatica by Intra-discal Injection of Proteolytic Enzymes (Nucleolysis),”La Nouvelle Presse Médicale, 9(4)227-230 (1980).
International Search Report for PCT/JP2003/016580, May 11, 2004.
Haro et al. “Up-Regulated Expression of Matrilysin and Neutrophil Collagenase in Human Herniated Discs”, Journal of Spinal Disorders (1999) vol. 12, No. 3, pp. 245-249.
Supplementary European Search Report dated Nov. 13, 2007.
Japanese Office Action issued Dec. 15, 2009, in JP 2005-509747.

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