Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-06-05
1998-07-28
Minnifield, Nita
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4242381, 42419711, 530326, 530327, 530328, 530329, 530330, 5303871, 5303881, 514 13, A61K 3900, A61K 39385, A61K 3800, C07K 500
Patent
active
057859701
ABSTRACT:
Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
REFERENCES:
patent: 3932242 (1976-01-01), Wissman et al.
patent: 4384995 (1983-05-01), Stevens
patent: 4526716 (1985-07-01), Stevens
patent: 4565805 (1986-01-01), Smirnov et al.
patent: 4687759 (1987-08-01), Martinez et al.
patent: 4691006 (1987-09-01), Stevens
patent: 5023077 (1991-06-01), Gevas et al.
patent: 5468494 (1995-11-01), Gevas et al.
patent: 5607676 (1997-03-01), Gevas et al.
patent: 5609870 (1997-03-01), Gevas et al.
patent: 5622702 (1997-04-01), Gevas et al.
Iwanaga et al. 1980. Biomed. Res. 1:316-320.
Bowie et al. 1990. Science 247: 1306-10.
Siemann. 1987 In:Rodent tumor models in Exptal Cancer Therapy. pp 12-15. Ed. Kallman. Pergamon Press NY.
Houghten 1986. Vaccines86. pp. 21-25. Ed. Brown.
Makishima et al, Gastroenterol. 106(4 Suppl) :A824. 1994.
Makishima et al, FASEB J., 8(4-5) : A92 Abstract#535. 1994.
Sugano et al., The Journal of Biological Chemistry, vol. 260, No. 21, Sep. 25, 1985, pp. 11724-11729.
Nemeth, et al., Izotoptechnika 25: 288-294, 1982.
Jaffe et al., Gastroenterology, vol. 58, No. 2, Feb. 1970, pp. 151-156.
Rae-Venter, et al. Gastroenterology 80; 1256, 1986.
Jaffe et al., Surgery, vol. 69, No. 2, Feb. 1971, pp. 232-237.
Jaffe et al., Surgery, vol. 65, No. 4, Apr. 1969, pp. 633-639.
Hughes et al., Digestive Diseases, vol. 21, No. 3, Mar. 1976, pp. 201-204.
Wunsch et al., Z. Physiol. Chem. Jun. 1982, pp. 666-669.
Larsson, Neurohistochemoistry; Modern Methods and Applications, 1986, pp. 527-567.
Moroder et al., Gastrin and Cholecystokinin, Chemistry, Physiology and Pharmacology, 1987, pp. 21-32.
Dockray et al., Gatroenterology, vol. 68, No. 2, Feb. 1975, pp. 222-230.
Choudhury et al., Z. Physiol. Chem., Nov. 1980, pp. 1719-1733.
Azuma et al. Gastroenterologia Japonica, vol. 21, No. 4, Aug. 1986, pp. 319-324.
Varndell et al., Experientia, 39, 1983, pp. 713-717.
Rehfeld et al. Scand. J. Clin. Lab. Invest., 30, 1972, pp. 221-232.
De Magistris et al., Analytical Biochemistry, 102, 1980, pp. 126-133.
Rehfeld et al., Regulatory Peptides, 2, 1981, pp. 333-342.
Yamaguchi, K., et al., Chem. Abs., 100: 15466lm, pp. 373, (1983).
Dockray, "Regulatory Peptides", 1, 169-186 (1980).
Yanaihara et al., "Biomedical Research", 1, 242-247 (1980).
Yanaihara et al., "Gut Peptides", 26-33 (1979).
Beauchamp et al., Ann.Surg., 202, Sep. 1985, pp. 303-309.
Lamote et al., Regulatory Peptides, 20, 1988, pp. 1-9.
Lamars et al., Eur. J. Cancer Clin. Oncol., vol. 24., No. 2, 1988, pp.267-273.
Watson et al., in vitro, Br. J. Surg., vol. 75, Apr. 1988, pp. 342-345.
Kusyk et al., Am. J. Physiol., 251, 1986, pp. G597-G601.
Weinstock et al., Cancer Research, 48, Feb. 15, 1988, pp. 932-937.
Rae-Venter et al., Gastroenterology, vol. 80, No. 5, 1986, p. 1256.
Smith et al., Digestive Diseases and Science, vol. 34, No. 2, Feb. 1989, pp. 171-174.
Smith et al., Gastroenterology, 95 1988, pp. 1541-1548.
Upp et al. Ann. Surg. vol. 207, No. 6, Jun. 1988 pp. 662-669.
Immunization with Hormones in reproduction Research, ed. Nieschlag, 1975, North Holland Publishing, pp. 107-117.
Gevas Philip C.
Grimes Stephen
Karr Stephen L.
Littenberg Richard L.
Aphton Corporation
Minnifield Nita
LandOfFree
Method of the treatment of gastrointestinal disorders with immun does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of the treatment of gastrointestinal disorders with immun, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of the treatment of gastrointestinal disorders with immun will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-20988