Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Reexamination Certificate
2006-06-27
2006-06-27
Tate, Christopher R (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
Reexamination Certificate
active
07067622
ABSTRACT:
It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.
REFERENCES:
patent: 6545162 (2003-04-01), Dervan et al.
patent: 6566336 (2003-05-01), Sugiyama et al.
patent: 6713633 (2004-03-01), Sugiyama et al.
patent: 6777425 (2004-08-01), Burli
patent: 2001-136974 (2001-05-01), None
patent: WO 97/23496 (1997-07-01), None
patent: WO 97/27327 (1997-07-01), None
patent: WO 97/30975 (1997-08-01), None
patent: WO 98/37066 (1998-08-01), None
patent: WO 98/45284 (1998-10-01), None
patent: WO 98/49142 (1998-11-01), None
Tao et al. Rational Design of Sequence-Specific DNA Alkylating Agents Based on Duocarmycin A and Pyrrole-Imidazole Hairpin Polyamides. J. Am. Chem. Soc. 1999, vol. 121, pp. 4961-4967.
Saito et al., “Fmoc Solid-Phase Synthesis of Pyrrole-Imidazole Polyamides,” Organics, vol. 79, Kanto Reagents (Mar. 2001).
Baird et al., “Solid Phase Synthesis of Polymides Containing Imidazole and Pyrrole Amino Acids,” Journal of the American Chemical Society, vol. 118, pp. 6141-6146, American Chemical Society (1996).
Vazquez et al., “An Fmoc Solid-Phase Approach to Linear Polypyrrole-Peptide Conjugates,” Tetrahedron Letters, vol. 40, pp. 3621-3624, Elsevier Science Ltd. (1999).
Satz et al., “Recognition of Nine Base Pairs in the Minor Groove of DNA by a Tripyrrole Peptide-Hoechst Conjugate,” Journal of the American Chemical Society, vol. 123, No. 11, pp. 2469-2477, American Chemical Society (Mar. 21, 2001).
International Search Report.
International Preliminary Examination Report.
Cho et al., “Cyclic Polyamides for Recognition in the Minor Groove of DNA,” Proceedings of the National Academies of Science USA—Chemistry, vol. 92, pp. 10389-10392 (Oct. 1995).
Xiao et al., “A Convenient Method for the Synthesis of DNA-Recognizing Polyamides in Solution,” Journal of Organic Chemistry, vol. 65, No. 18, pp. 5506-5513, American Chemical Society (2000).
Wurtz et al., “Fmoc Solid Phase Synthesis of Polyamides Containing Pyrrole and Imidazole Amino Acids,” Organic Letters, vol. 3, No. 8, pp. 1201-1203, American Chemical Society (2001).
Iida Hirokazu
Saito Isao
Saito Takashi
Sugiyama Hiroshi
Cordero Garcia Marcela M
Japan Science and Technology Agency
Rader, Fishmen & Grauer PLLC
Tate Christopher R
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