Method of the production of immunoglobulin having high content o

Details Method of the production of immunoglobulin having high content o Method of the production of immunoglobulin having high content o

1980-08-08

1983-05-24

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, 424101, C07G 700

Patent

active

043849938

ABSTRACT:
A method of the production of immunoglobulin having a high content of monr from immunoglobulin-containing materials by a fractionation method, which comprises carrying out the fractionation in the presence of a water-soluble, basic nitrogen-containing organic compound having a dissociation constant (pKb) of 7 or less or an acid addition salt thereof, and thereby inhibiting by-production of undesirable aggregated molecules. The immunoglobulin has a high content of monomer and contains no or little aggregated molecules and hence can be used as a medicine in immune prophylaxis and immunotherapy without undesirable side effects and can be administered by intraveneous route, and further, is useful for the preparation of chemically treated immunoglobulin having a high content of monomer.

REFERENCES:
patent: 4059571 (1977-11-01), Tomibe et al.
patent: 4118379 (1978-10-01), Schmidtberger
Acta Chemica Scandinavica, vol. 22, 1968, No. 2, 490-496, Hansson.

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