Method of the preparation of improved mutant strain of Bordetell

Details Method of the preparation of improved mutant strain of Bordetell Method of the preparation of improved mutant strain of Bordetell

1982-07-21

1984-06-26

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4351721, 435253, A61K 3910, C12N 1500, C12N 100

Patent

active

044565887

ABSTRACT:
A method for the preparation of a new mutant strain of Bordetella bronchiseptica having a plural of hereditary chromosomal markers of at least temperature-sensitivity and urease negative, more particularly a phase I mutant strain of B. bronchiseptica having excellent immunity and high safety, which is useful for the preparation of a live attenuated vaccine for prophylaxis of B. bronchiseptica infection, and also a live attenuated vaccine prepared therefrom, and use thereof.

REFERENCES:
patent: 4225583 (1980-09-01), Switzer et al.
Shimizu, Ti, Infection and Immunity, vol. 22, pp. 318-321, 1978.

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