Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Glycoproteins
Patent
1993-05-03
1996-11-05
Soderquist, Arlen
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Glycoproteins
436 14, 436 88, 436 95, 436175, 436177, 436811, 436904, G01N 3349, G01N 118
Patent
active
055717233
ABSTRACT:
An improved method of testing individuals for diabetes, even if they have levels of interfering substances (e.g., uric acid, bilirubin, and glutathione) that would otherwise interfere with such testing, is disclosed. The individual's protein-bound glucose level and glucose level are compared to the analogous values for a reference population to enable the risk of that individual's having diabetes to be assessed. The substances that would otherwise tend to interfere with the assay for protein-bound glucose are removed before the assay, desirably by precipitating the protein-bound glucose using uranyl acetate, which desirably leaves substantially all of the interfering substances in the supernatant, then separating the precipitate from the supernatant, redissolving the precipitate, and conducting the colorimetric assay on the resulting solution. An improved colorimetric test for protein-bound glucose using viologens as the colorimetric electron acceptors is also disclosed.
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Bates Harold M.
Evans Cody A.
Cave LLP Bryan
Soderquist Arlen
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