Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-01-09
2007-01-09
Saunders, David (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C004S590000, C004S590000, C004S590000, C004S590000, C436S086000
Reexamination Certificate
active
10214793
ABSTRACT:
SCCA1 and SCCA2 genes, whose expression were greatly changed in a plurality of cells by stimulating respiratory tract epithelial cells with IL-4 or IL-13, were obtained as allergy related genes. Furthermore, elevation of blood level of expression products of these genes accompanying bronchial asthmatic attack was elucidated. This invention provides a method of testing for bronchial asthmatic attack that uses as indicators, expression levels of these genes in biological samples.
REFERENCES:
patent: 2003/0099979 (2003-05-01), Ohtani et al.
Cheah et al., J Clinical Pathology, vol. 47, pp. 535-537, 1994.
Akimoto et al., “Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice,” J. Exp. Med., 187:1537-1542 [1998].
Berger and Kimmel, “Guide to Molecular Cloning Techniques,” Method in Enzymology, Academic Press Inc., Orlando, FL [1987] title and copyright pages.
Borish et al., “Interleukin-4 receptor in moderate atopic asthma,” Am. J. Respir. Crit. Care Med., 160:912-922 [1999].
Cataltepe et al., “Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2,” Clin. Chim. Acta, 295:107-127 [2000].
Gibson et al., “A novel method for real time quantitative RT-PCR,” Genome Research, 6:995-1001 [1996].
Grunig et al., “Requirement for IL-13 Independently of IL-4 in experimental asthma,” Science, 282:2261-2263 [1998].
Hames and Higgins,Genes Probes: A Practical Approach, IRL Press, Oxford [1985] title and copyright pages.
Heid et al., “Real time quantitative PCR,” Genome Research, 6:986-994 [1996].
Heinzmann et al., “Genetic variants of IL-13 signalling and human asthma and atopy,” Hum. Mol. Genet., 9:549-559 [2000].
Holland et al., “Detection of specific polymerase chain reaction product by utilizing the 5′ → 3′ exonuclease activity ofThermus aquaticusDNA polymerase,” Proc. Natl. Acad. Sci., USA, 88:7276-7280 [1991].
Kricka, “Nonisotopic DNA Probing Techniques,” Academic Press Inc., San Diego, CA [1992] title and copyright pages.
Kruse et al., “The polymorphisms S503P and Q576R in the interleukin-4 receptor α gene are associated with atopy and influence the signal transduction,” Immunol., 96:365-371 [1991].
Livak et al., “Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization,” PCR Methods and Applications, 4:357-362 [1995].
Melton et al., “Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter,” Nucleic Acid Res., 12:7035-7056 [1984].
Milstein and Cuello, “Hybrid hybridomas and their use in immunohistochemistry,” Nature, 305:537-40 [1983].
Mitsuyasu et al., “Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma,” Nature Genet., 19:119-120 [1998].
Mitsuyasu et al., “Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis,” J. Immunol., 162:1227-1231 [1999].
Sambrook et al.,Molecular Cloning: a Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press [1989] title and copyright pages provided.
Schick et al., “Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase,” J Biol. Chem., 272:1849-1855 [1997].
Schick et al., “Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis,” Biochemistry, 37:5258-5266 [1998].
Schneider et al., “A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene,” Proc. Natl. Acad. Sci. USA, 92:3147-3151 [1995].
Wang et al., “Effects of IL-4 and IL-13 on gene regulation and signal transduction of the primary human airway tissue cells,” Abstract presented at the Joint Meeting of the CIS and AAI, entitled Immunology 2000, Seattle, WA May 12-16, 2000.
Wills-Karp et al., “Interleukin-13: Central Mediator of Allergic Asthma,” Science, 282:2258-2261 [1998].
Yssel and Groux, “Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic disease,” Int. Arch. Allergy Immunol., 121:10-18 [2000].
Zhu et al., “Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production,” J. Clin. Invest., 103:779-788 [1999].
Izuhara, “A microarray-based approach to search for bronchial asthma-related genes,” Allergology and Immunology, 8:1148-1152 [2001] Japanese publication and English translation.
Noguchi et al., “Haplotypes of the 5′ region of the IL-4 gene and SNPs in the intergene sequence between and IL-4 and IL-13 genes are associated with atopic asthma,” Hum. Immunol., 62:1251-1257 [2001].
Schick et al., “Cross-class inhibition of elastolytic cysteine proteinases by the human serpin SCCA1,” Pediatric Research, 41:306A [1997].
Symula et al., “Functional screening of an asthma QTL in YAC transgenic mice,” Nat. Genet., 23:241-244 [1999].
Izuhara, “Bronchial epithelial cells and Th2 type cytokine,” English translation of an abstract presented at the 50th Annual Meeting of the Japanese Society of Allergology, Nov. 30-Dec. 2, 2000.
Kawashima et al., Squamous cell carcinoma-related antigen in children with atopic dermatitis, Pediatr. Int., 42:448-450 [2000].
Kuperman et al., “Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma,” Nat. Med., 8:885-889 [2002].
Lee et al., “Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types,” Am. J. Cell Mol. Biol., 25:474-485 [2001].
Matsui et al., “Identificationof genes influenced by IL-4 and IL-13 in human bronchial epithelium and bronchial smooth muscle cells,” English translation of an abstract presented at the 30th Annual Meeting of the Japanese Society for Immunology, Nov. 14-16, 2000.
Rivas et al., “Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique,” J. Invest. Dermatol., 108:188-194 [1997].
Shepard, “Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury and emphysema,” Chest, 121:21S-25S [2002].
Yuyama et al., “Identification of genes influenced by IL-4 or IL-13 in human bronchial epithelium and bronchial smooth muscle cells,” English translation of an abstract presented at the 50th Annual Meeting of the Japanese Society of Allergology, Nov. 30-Dec. 2, 2000.
Yuyama et al., “The analysis of squamous cell carcinoma antigen (SCCA), whose expression is induced by IL-4 and IL-13 in human bronchial epithelial cells,” English translation of an abstract presented at the 51th Annual Meeting of the Japanese Society of Allergology, Oct. 29-31, 2001.
Yuyama et al., “Analysis of novel disease-related genes in bronchial asthma,” Abstract presented at the Keystone Symposium entitled Rethinking the Pathogenesis of Asthma, Santa Fe, NM, Feb. 8-13, 2002.
Yuyama et al., “Analysis of novel disease-related genes in bronchial asthma,”Cytokine, 19:287-296, 2002.
Stenman et al., “Detection of squamous-cell carcinoma antigen-expressiong tumour cells in blood by reverse transcriptase-polymerase chain reaction in cancer of the uterine cervix,”Int J Cancer(Pred Oncol), 74:75-80, 1997.
Hamasaki Yuhei
Izuhara Kenji
Matsui Keiko
Ohtani Noriko
Sugita Yuji
Genox Research, Inc.
Medlen & Carroll LLP
Saunders David
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