Method of testing for allergic diseases

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07148011

ABSTRACT:
The differential display method was used to search for a gene whose expression level in eosinophils collected from patients with atopic dermatitis differs in the exacerbation stage and in the remission stage. As a result, gene “2090-05” showing a significant increase in expression in eosinophils of patients in the remission stage was isolated. This gene is usable in testing for an allergic disease and screening for a candidate compound for a therapeutic agent therefor an allergic disease.

REFERENCES:
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patent: WO 00/20571 (2000-04-01), None
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patent: WO 00/65046 (2000-11-01), None
patent: WO 02/26962 (2002-04-01), None
Hillier et al. “Generation and Analysis of 280,00 human expressed sequence tags”, Genome Research, 1996, 6, 807-828.
Sequence alignment—Result 4, Baughn et al., p. 5-7.
Hillier et al., “Generation and Analysis of 280,000 Human Expressed Sequence Tags,”Genome Res. 6:807-828 (1996).
Ito et al., “Fluorescent Differential Display: Arbitrarily Primed RT-PCT Fingerprinting on an Automated DNA Sequencer,”FEBS Letters 351:231-236 (1994).
Liang et al., “Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction,”Science 257:967-971 (1992).

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