Method of testing adequacy of cells in a specimen

Details Method of testing adequacy of cells in a specimen Method of testing adequacy of cells in a specimen

2005-09-06

2005-09-06

Wax, Robert A. (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

C435S029000, C435S173400, C435S040500, C435S006120

Reexamination Certificate

active

06939687

ABSTRACT:
The present invention provides a device and method for determining the adequacy of squamous (ectocervical) cells, columnar (endocervical) cells, neutrophils, and noncellular material in a liquid based cytology specimen. The invention first analyzes a liquid based cytology specimen using light scatter to create a light scatter characteristic representing a predetermined cell. Next the invention determines the presence of squamous (ectocervical) cells versus columnar (endocervical) cells versus neutrophils versus noncellular material using the results of the light scatter. The light scatter characteristic that may be used may be forward light scatter, side light scatter, or both side and forward light scatter.

REFERENCES:
patent: 4475236 (1984-10-01), Hoffman
patent: 63058258 (1988-03-01), None
Vidal-Vanaclocha et al., “Isolation and enrichment of two sublobular compartment-specific endothelial cell subpopulations from liver sinusoids,” Hepatology 18(2):328-339-, 1993.
Barrett et al., “Cytomorphology of Gynecologic Specimens Analyzed and Sorted by Two-Parameter Flow Cytometry” Acta Cytol 22(1):7-14, 1978.

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