Method of testing a material without the use of animals to deter

Details Method of testing a material without the use of animals to deter Method of testing a material without the use of animals to deter

1998-04-30

2000-08-01

Ludlow, Jan

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Surface area, porosity, imperfection, or alteration

436 6, 436 71, 436 86, 436166, 422 8209, 422 8211, G01N 3100

Patent

active

060965509

ABSTRACT:
A method of testing a material without the use of animals to determine the potential of the material to harm human or animal cells due to contact includes forming a biomembrane having at least some constituent matter of human or animal tissue, applying a quantity of material to the membrane, maintaining the biomembrane and quantity of material in contact for a period of time, and monitoring the change in the physical properties of the biomembrane caused by the quantity of material.

REFERENCES:
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Chemical Abstracts (Columbus, OH) Abstract No. CA121:170775, Levy et al., Skin Pharmacol. (1994), 7(4), pp. 231-236, 1994.
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Polymer Thin Films and Interfaces Characterized With Evanescent Light, W. Knoll, Makromol. Chem. 192, No. 12, Dec. 1991, pp. 2827-2856.

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