Method of testing a donor liver for transplant

Details Method of testing a donor liver for transplant Method of testing a donor liver for transplant

1992-05-19

1993-11-09

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 721, 435 29, 436 29, C12Q 100

Patent

active

052601889

ABSTRACT:
A method for determining the suitability of an organ for transplant by performing one or more tests on the endothelial cells lining the blood vessels in the organ prior to the transplant operation. Specifically hyaluronic acid is used as the measure to determine liver transplant effectiveness.

REFERENCES:
Adams, D. H. et al Transplantation vol. 47, pp. 479-482 (1989).
Polard et al. Transplantation Proceedings, vol. 22 pp. 2301-2302 (1990).
Hallgren et al J Exp Med. vol. 171 pp. 2063-2076 (1990).
Wells et al. Transplantation, vol. 50, pp. 240-243 (1990).
Hallgren et al J Clin Investigation vol. 85, pp. 668-673 (1990).
S. Todo et al., "Extended Preservation of Human Liver Grafts with UW Soluon," JAMA, vol. 261, No. 5, (Feb. 3, 1989), pp. 711-714.
Shaw, B. W., Jr. et al., "Improved Results with Retransplantation of the Liver," Transplantation Proceedings, vol. 21, No. 1, (Feb. 1989), pp. 2407-2408.
A. W. Paulsen et al., Transplantation Proceedings, vol. 21, No. 1, (Feb. 1989), pp. 2337-2338.
H. Furukawa et al., "Effect of Cold Ischemia Time on the Early Outcome of Human Hepatic Allografts Preserved with UW Solution," Transplantation, vol. 51, No. 5, (May 1991), pp. 1000-1004.
T. E. Starzl et al., "Liver Transplantation," The England Journal of Medicine, vol. 321, No. 15, (Oct. 12, 1989), pp. 1014-1021.
G. Otto et al., "Preservation Damage in Liver Transplantation," Transplantation, vol. 42, No. 2, (Aug. 1986), pp. 122-124.
C. M. B. McKeown et al., "Sinusoidal Lining Cell Damage: The Critical Injury in Cold Preservation of Liver Allografts in the Rat," Transplantation, vol. 46, No. 2, (Aug. 1988), pp. 178-191.
P. N. Rao et al., "Purine Nucleoside Phosphorylase: A New Market for Free Oxygen Radical Injury to the Endothelial Cell", Hepatology, vol. 11, No. 2, (1990), pp. 193-198.
H. J. Mischinger et al., "Levels of Purine Nucleoside Phosphorylase (PNP) as a Viability Marker of Nonparenchymal Cells in Cold Preserved Livers," Transplantation, vol. 23, No. 1, (Feb. 1991), pp. 222-225.
S. Kakizoe et al., "Evaluation of Protocol before Transplantation and after Reperfusion Biopsies from Human Orthotopic Lever Allografts: Considerations of Preservation and Early Immunological Injury," Hepatology, vol. 11, No. 6, (Jun. 1990), pp. 932-941.
E. R. DeLong et al., "Comparing the Areas Under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach," Biometrics, vol. 44, No. 837-845, (Sep. 1988), pp. 837-845.
L. Makowka, R. D. et al., "Analysis of Donor Criteria for the Prediction of Outcome in Clinical Liver Transplantation," Transplantation Proceedings, vol. XIX, No. 1, (Feb. 1987), pp. 2378-2382.

Affiliated with

Also associated with

Rating

Method of testing a donor liver for transplant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of testing a donor liver for transplant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of testing a donor liver for transplant will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1142170