Method of synthesizing sulfurized oligonucleotide analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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558122, C07H 2100

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052928756

ABSTRACT:
A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosophoramidite and/or phosphorthioamidite intermediates.

REFERENCES:
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Jacobson et al, J. Amer. Chem. Soc., 77:6064-6065 (1955).
Tolmacheva et al, J. of General Chemistry of the USSR, 48: 982-984 (1978).
Michalski et al, Roczniki Chemii, 33:247-259 (1958).
Matsukura et al, Gene, 72:343-347 (1988).

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