Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-08-27
1994-03-08
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
558122, C07H 2100
Patent
active
052928756
ABSTRACT:
A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosophoramidite and/or phosphorthioamidite intermediates.
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Tolmacheva et al, J. of General Chemistry of the USSR, 48: 982-984 (1978).
Michalski et al, Roczniki Chemii, 33:247-259 (1958).
Matsukura et al, Gene, 72:343-347 (1988).
Bergot B. John
Fearson Karen L.
Hirschbein Bernard L.
Stec Wojciech J.
Uznanski Bogdan
Ambrose Michael G.
Lee Mary C.
Lynx Therapeutics, Inc.
Macevicz Stephen C.
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