Method of synthesizing saccharide compositions

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 74, 435 75, 435 84, 435193, 4352523, 43525233, 4353201, 4352891, 536 232, C12P 1900, C12M 136

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058799125

ABSTRACT:
A method of synthesizing saccharide compositions is described. In this method, an acceptor moiety is contacted with at least one donor saccharide in the presence of at least one cell surface-bound glycosyltransferase specific for catalyzing the coupling of the acceptor moiety with the donor saccharide. The acceptor moiety used is a carbohydrate, a protein, a glycolipid, a lipid, or a glycolipid.

REFERENCES:
patent: 4590160 (1986-05-01), Nishihashi et al.
patent: 5032519 (1991-07-01), Paulson et al.
patent: 5047335 (1991-09-01), Paulson et al.
patent: 5135854 (1992-08-01), Mackay et al.
patent: 5141858 (1992-08-01), Paul et al.
patent: 5149640 (1992-09-01), Oonishi et al.
patent: 5180674 (1993-01-01), Roth
patent: 5324663 (1994-06-01), Lowe
patent: 5348867 (1994-09-01), Georgiou et al.
patent: 5545553 (1996-08-01), Gotschlich
Mukasa et al., 1989, "Purification and Characterization of Cell-associated Glucosyltransferase Synthesizing Insoluble Glucan from Streptococcus mutans Serotype c", J. Gen. Microbiol. 135:2055-2063.
Yamamoto, et al., The Journal of Biological Chemistry, vol. 265, No.2, pp. 1146-1151, 1990.
Pierce, et al. International Review of Cytology, vol. 65, pp. 1-47, Cell Surface Glycosyltransferase Activities, 1980.
Larsen et al., Proc.Natl.Acad.Sci.USA 86,pp. 8227-8231, Nov. 1989.
Francisco, et al., Proc.Natl.Acad.Sci.USA, vol.89, pp. 2713-1717, Apr. 1992.
Larsen, et al., Proc.Natl.Acad.Sci.USA, vol.87, pp. 6674-6678, Sep. 1990.
Lowe, et al., The Journal of Biological Chemistry, 1991, vol.266,No.26, pp. 17647-17477, 1991.
Charbit, et al., The EMBO Journal, vol.5, No. 11, pp. 3029-3037, 1986.
Charbit, et al., Gene, vol.70, No. 1, pp. 181-189, 1988.
Agterberg, et al., Gene, vol.88, No. 1, pp. 37-45, 1990.
Freudl, et al., Gene, vol.82, No. 2, pp. 229-236, 1989.
Ghrayeb, et al., The Journal of Biological Chemistry, vol. 259, No.1, pp. 463-467, 1984.
Charbit, et al., The Journal of Bacteriology, vol. 173, No.1, pp. 262-275, 1991.
Evans, et al. The Journal of Cell Biology, vol. 120, No.4, Feb. 1993, pp. 1045-1057.
Kadam, et al., The Journal of Bacteriology, vol. 161, No.1, Jan.1985, pp. 277-284.
Stephen Roth, Glycosyltransferases as Effectors of Cell Recognition, Chapter 5. pp. 201-223 (1990).
Thiry, et al., Applied and Environmental Microbiology, vol. 55, Apr. 1989, pp. 984-993.
Creeger, et al., Methods in Enzymology, vol.83, 1982, Complex Carbohydrates, Part D, pp. 326-331.
Kojima, et al., Biochemical and Biophysical Research Communications, vol.143, No. 2, 1987, pp. 716-722.
Yogeeswaran et al, "Mechanism of Cell Contact-Dependent Glycolipid Synthesis . . . ", Biochem. Biophys. Res. Comm. 59(2):591-599 (1974).
Patt et al, "Ectoglycosyltransferase Activity in Suspensions . . .of Fibroblasts . . . " Biochem. Biophys. Res. Comm. 67(1):483-490 (1975).
LaMont et al, "Cell-surface glycosyltransferases in cultured fibroblasts . . . " PNAS 74(3):1086-1090 (Mar. 1977).
Patt et al, "Cell Surface Glycolipid and Glycoprotein Glycosyltransferases . . . " J. Biol. Chem. 249(13):4157-4165 (Jul. 1974).
Weiser, "Intestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis", J. Biol. Chem. 248(7):2542-2548 (Apr. 1973).
Rawn, Biochemistry, pp. 548-554, 878-882, Neil Patterson Publishers, NC (1989).
Aoki etal, "Golgi retention of a trans-Golgi membrane protein, galactosyl-transferase . . . " PNAS 89: 4319-4323 (May 1992).
Teasdale etal "The Signal for Golgi Retention of Bovine .beta.1,4-Galactosyl-transferase", J. Biol. Chem. 267(6):4084-4096 (Feb. 1992).
Paulson etal "Glycosyltransferases", J. Biol. Chem. 264(30):17615-17618, (Oct. 1989).

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