Method of synthesizing quinoxaline derivative by microwave...

Details Method of synthesizing quinoxaline derivative by microwave... Method of synthesizing quinoxaline derivative by microwave...

2011-06-28

2011-06-28

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

07968713

ABSTRACT:
There is disclosed a method of synthesizing a quinoxaline derivative in which toxicity, corrosiveness and permeation are low and which is excellent in safety and which attains a reduced reaction time, a greatly improved yield and excellent economical efficiency. The object is achieved by a method of synthesizing a quinoxaline derivative which comprises adsorbing a benzofuroxan derivative and a β-diketone derivative on a solid support, and then heating the derivatives in a solid state by microwave irradiation to dehydrocyclize them. An example of a quinoxaline derivative is a compound of formula (4):

REFERENCES:
patent: 4343942 (1982-08-01), Issidorides et al.
patent: 2004/0242684 (2004-12-01), Chen et al.
patent: 2297089 (1996-07-01), None
patent: WO 95/24190 (1995-09-01), None
Haddadin, et al. JOC, 36(4), 1971, 514-518.
Haddadin, et al. Tetrahedron, 32(6), 1976, 719-724.
Tohru Takabatake, et al., “Synthesis and Antibacterial Properties of Quinoxaline 1,4-Dioxide Derivatives,” Yakugaku Zasshi, vol. 116 (6), p. 491-496, 1996.
Hala U. Gali-Muhtasib,et al., “Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs,” Oncology Reports vol. 8, p. 679-684, 2001.
Antonio Monge, et al., “Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides,” J. Med. Chem. vol. 38, p. 1786-1792, 1995.
Adil A. Jarrar, et al., “Photolysis of Some Quinoxaline-1,4-dioxides. A Method of Structural Assignment,” Heterocycles, vol. 4, No. 6, p. 1077-1082, 1976.
Costas H. Issidorides, et al., “Benzofurazan Oxide. II. Reactions with Enolate Anions,” Journal of Organic Chemistry, vol. 31, p. 4067-4068, 1966.
Tohru Takabatake, et al., “The Reactions of Benzofuroxan with Carbonyl Compounds on the Surface of Solid Catalysts,” Journal of Heterocyclic Chemistry, vol. 30 (6), p. 1477-1479, 1993.
Nobuo Sekimura, et al., “Synthesis of quinoxaline 1,4-dioxides from 5,6-diethylbenzofuroxan on silica gel,” Heterocycles, vol. 65, No. 7, p. 1589-1600, 2005.
Hideko Koshima, “Use of Microwaves in Organic Synthesis,” Kagaku Kougyou, p. 58-63, 2002.
Masao Tokuda, “Environmentally Benign Organic Synthesis,” Kagaku Kougyou, p. 21-25, 2002.
Andres Jaso, et al, “Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosisagents,” European Journal of Medicinal Chemistry, vol. 38 (9), p. 791-800, 2003.

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