Method of synthesizing camptothecin-relating compounds

Details Method of synthesizing camptothecin-relating compounds Method of synthesizing camptothecin-relating compounds

2006-09-08

2008-05-27

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S394000

Reexamination Certificate

active

07378555

ABSTRACT:
The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.

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