Method of synthesizing and purifying Dkk proteins and Dkk...

Details Method of synthesizing and purifying Dkk proteins and Dkk... Method of synthesizing and purifying Dkk proteins and Dkk...

2011-01-11

2011-01-11

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C530S350000

Reexamination Certificate

active

07867699

ABSTRACT:
The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.

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Shou Jiang et al. “Human Dkk-1, a gene'encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.”Oncogene, vol. 21, No. 6, Jan. 31, 2002, pp. 878-889.
Glinka et al. “Dickkopf-1 is a member of a new family of secreted proteins and function in head induction.”Nature, vol. 391, No. 6665, Jan. 22, 1998, pp. 357-362.
Fedi et al. “Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling.”The Journal of Biological Chemistry, vol. 274, No. 27, Jul. 2, 1999, pp. 19465-19472.

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