Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil

Details Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil

1974-05-06

1976-06-01

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D23954

Patent

active

039608646

ABSTRACT:
An improved method for synthesizing 1-(tetrahydro - 2-furanyl) - 5-fluorouracil from a silyl derivitive of 5-fluorouracil (bis - trimethylsilyl 5-fluorouracil) by reacting the same with 2-chlorotetrahydrofuran. The reaction is carried out at controlled conditions of temperature and under an inert gas. Yields in excess of 80% of the theoretical are obtained as calculated upon the starting amounts of 5-fluorouracil.

REFERENCES:
Earl et al., Journal of Heterocyclic Chemistry 9, 1141 (1972).

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