Method of synthesis of trans-2-phenylcyclopropylamine

Details Method of synthesis of trans-2-phenylcyclopropylamine Method of synthesis of trans-2-phenylcyclopropylamine

1975-10-31

1977-04-05

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605705CA, C07C 6352

Patent

active

040162044

ABSTRACT:
An improved method of synthesis of trans-2-phenylcyclopropylamine wherein the improvement comprises isomerizing an intermediate ester, namely, cis,trans-ethyl-2-phenylcyclopropanecarboxylate, by reacting said ester with anhydrous sodium ethoxide, to form a reaction product containing not more than about 5 percent cis ester and further reacting said resultant product to form trans-2-phenylcyclopropylamine.

REFERENCES:
patent: 2997422 (1961-08-01), Tedeschi
patent: 3050559 (1962-08-01), Burger
patent: 3153092 (1964-10-01), Burger
Burger et al., J.A.C.S., 70, 2198 (1948).
Walborsky et al., J.A.C.S., 83, 2138 (1961).
Burger et al., J. Med. Pharm. Chem., 4, 571 (1961).
Kaiser et al., J. Med. Pharm. Chem., 5, 1243 (1962).

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