Method of synthesis of desulfated heparin and use thereof for in

Details Method of synthesis of desulfated heparin and use thereof for in Method of synthesis of desulfated heparin and use thereof for in

1999-06-14

2000-06-20

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, 536 21, 514 56, C12Q 137, C12Q 100

Patent

active

060776838

ABSTRACT:
A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administering a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is administered by aerosolization or by intravenous (IV) injection. Preferably, the 2-O-desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline, and distilled water. Additionally provided is a method of synthesizing 2-O-desulfated heparin.

REFERENCES:
patent: 4816446 (1989-03-01), Feller et al.
patent: 5296471 (1994-03-01), Holme et al.
patent: 5668118 (1997-09-01), Kennedy
patent: 5912237 (1999-06-01), Kennedy
L. Levy et al., "Chemical and Pharmacological Studies on N-Sulfated Heparin", Proc. Soc. Exp. Biol. and Med., 109:901-905 (1962).
F. Redini et al., "Influence of Heparin Fragments on the Biological Activities of Elastase(s) and Alpha.sub.1 Proteinase Inhibitor", Biochem. Pharmacol., 37:4257-5261 (1988).
F. Redini et al., "Inhibition of Leukocyte Elastase by Heparin and its Derivatives", Biochem. J., 252:515-519 (1988).
M. Jaseija et al., "Novel Regio-and Stereoselective Modifications of Heparin in Alkaline Solution. Nuclear Magnetic Resonance Spectroscopic Evidence", Can. J. Chem., 67:1449-1456 (1989).
E. Sache et al., "Partially N-Desulfated Heparin as a Non-Anticoagulant Heparin: Some Physico-Chemical and Biological Properties", Thromb. Res., 55:247-258 (1989).
N.V. Rao et al., "Sulfated Polysaccharides Prevent Human Leukocyte Elastase-Induced Acute Lung Injury and Emphysema in Hamsters", Am. Rev. Respir. Dis., 142:407-412 (1990).
T. Irimura et al., "Chemically Modified Heparins as Inhibitors of Heparan Sulfate Specific Endo-.beta.-glucuronidase (Heparanase) of Metastiatic Melanoma Cells", Biochemistry, 25:5322-5328 (1986).
Nagasawa et al., "Hydrophobic-Interaction Chromatography of Glycosaminoglycuronans", Carb. Res. 111:273-281 (1983).

Affiliated with

Also associated with

Rating

Method of synthesis of desulfated heparin and use thereof for in does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of synthesis of desulfated heparin and use thereof for in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of synthesis of desulfated heparin and use thereof for in will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1850904