Method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-py

Details Method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-py Method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-py

1993-05-25

1995-01-31

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40100

Patent

active

053860322

ABSTRACT:
The present invention relates to an improved method for the synthesis of omeprazole, comprising the steps of reacting 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimida zole with m-chloroperoxybenzoic acid in a methylene chloride solution at a substantially constant pH of about 8.0 to 8.6; extracting the reaction mixture with aqueous NaOH; separating the aqueous phase from the organic phase; and adding an alkyl formate to the aqueous phase, resulting in crystallization of omeprazole.

REFERENCES:
patent: 4182766 (1980-01-01), Krasso
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4307102 (1981-12-01), Bell
patent: 4686230 (1987-08-01), Rainer et al.
patent: 4996217 (1991-02-01), Honma et al.
patent: 5002945 (1991-03-01), Honma et al.

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