Method of synergistic treatment for benign prostatic hyperplasia

Details Method of synergistic treatment for benign prostatic hyperplasia Method of synergistic treatment for benign prostatic hyperplasia

1998-02-20

2000-04-04

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514176, 514260, 514257, A61K 3156, A61K 3158, A61K 31505

Patent

active

060461837

ABSTRACT:
Disclosed is an improved treatment for men with benign prostatic hyperplasia (BPH), involving combination therapy of a 5.alpha.-reductase inhibitor, e.g. a 17.beta.-substituted 4-azasteroid, a 17.beta.-substituted non-azasteroid, 17.beta.-acyl-3-carboxy-androst-3,5-diene, benzoylaminophenoxybutanoic acid derivative, fused benz(thio)amide or cinnamoylamide derivative, aromatic 1,2-diethers or thioethers, aromatic ortho acylaminophenoxy alkanoic acids, ortho thioalkylacylaminophenoxy alkanoic acids, pharmaceutically acceptable salts and esters thereof, and particularly finasteride, in combination with an .alpha..sub.1 -adrenergic receptor blocker, i.e., terazosin. The combination provides therapy at the molecular level for the underlying cause of the disease as well as providing symptomatic relief. Pharmaceutical compositions useful for treatment are also disclosed.

REFERENCES:
patent: 3511836 (1970-05-01), Hess
patent: 3527761 (1970-09-01), Archibald et al.
patent: 3920636 (1975-11-01), Takahashi et al.
patent: 3980650 (1976-09-01), Nauta
patent: 4026894 (1977-05-01), Winn et al.
patent: 4188390 (1980-02-01), Campbell
patent: 4220775 (1980-09-01), Rasmusson et al.
patent: 4315007 (1982-02-01), Manoury
patent: 4377584 (1983-03-01), Rasmusson et al.
patent: 4732897 (1988-03-01), Cainelli et al.
patent: 4760071 (1988-07-01), Rasmusson et al.
patent: 4845104 (1989-07-01), Carlin et al.
patent: 4859681 (1989-08-01), Rasmusson et al.
patent: 4882319 (1989-11-01), Holt et al.
patent: 4888336 (1989-12-01), Holt et al.
patent: 4910226 (1990-03-01), Holt et al.
patent: 5212176 (1993-05-01), Kyncl et al.
Nieschlag et al., Z. Klin. Chem. u. klin. Biochem. (1972), pp. 164-168, "Radioimmunoassay for plasma testosterone".
Kumamoto et al., Hinyokika Kiyo, vol. 33 (1987), pp. 1921-1922, "Clinical efficacy of oxendolene (antiandrogen) and bunazosin hydrochloride (alpha-adrenergic blocker) . . . ".
Kumamoto et al., Hinyokika Kiyo, vol. 33 (1987), pp. 1921-1922, "Clinical efficacy of oxendolene (antiandrogen) and bunazosin hydrochloride (alpha-adrenergic blocker) . . . ".
Caine et al., Chem. Abstracts, vol. 102(11):90035s, "The effect of nicergoline on the lower urinary tract muscle" Date needed.
Caine et al., British J. of Urology, vol. 48 (1976), pp. 255-263, "The use of alpha-adrenergic blockers in benign prostatic obstruction".
Neri et al., Investigative Urology, vol. 10 (1972), pp. 123-130, "Effects of novel nonesteroidal antiandrogen on canine prostatic hyperplasia".
The Daily, May 7, 1996, "New data on Proscar, Abbott's Hytrin show conflicting results".
Wall Street Journal, May 7, 1996, p. B4, "Study finds Abbott's prostate drug is much more effective than Merck's".
US News & World Report, May 20, 1996, "Zapping a problem prostate".
Lepor, N. Engl. J. of Med., vol. 335 (1996), pp. 533-539, "The efficacy in terazosin, finasteride, or both of benign prostatic hyperplasia".
Vapnek et al., Abstracts Western Section AUA, 72nd Annual Meeting (1996), "Combination medical therapy for symptomatic benign prostatic hyperplasia".
Walsh, N. Engl. J. of Med., vol. 335 (1996), pp. 585-588, "Treatment of benign prostatic hyperplasia".
CA:109:163450 (Iepor et al.), 1988.

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