Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-02-23
2000-10-17
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514678, A61K 31355, A61K 3112
Patent
active
061333123
ABSTRACT:
A method of inhibiting the growth of tumor cells is disclosed. In one embodiment, this method comprises the step of exposing tumor cells to an effective amount of a composition comprising at least two compounds selected from the group consisting of tocotrienols, statins and ionones.
REFERENCES:
patent: Re33885 (1992-04-01), Mattson
patent: Re34617 (1994-05-01), Jandacek et al.
patent: 4789554 (1988-12-01), Scavone et al.
patent: 5157132 (1992-10-01), Tan et al.
patent: 5190618 (1993-03-01), Top et al.
patent: 5204373 (1993-04-01), Pearce et al.
patent: 5217992 (1993-06-01), Wright et al.
patent: 5376361 (1994-12-01), Perricone
patent: 5391765 (1995-02-01), Pearce et al.
patent: 5393776 (1995-02-01), Pearce
patent: 5411969 (1995-05-01), Pearce et al.
patent: 5475029 (1995-12-01), Bradfute et al.
patent: 5500154 (1996-03-01), Bacon et al.
patent: 5554647 (1996-09-01), Perricone
patent: 5574063 (1996-11-01), Perricone
patent: 5591772 (1997-01-01), Lane et al.
patent: 5605930 (1997-02-01), Samid
Yu et al., J. Agric. Food Chem., 43(8), 2144-7 Abstract Only, 1995.
C.E. Elson, "Novel lipids and cancer: Isoprenoids and other phytochemicals," Dietary Fats, Lipids, Hormones, and Tumorigenesis; Heber and Kritchevsky, Plenum Press, New York, pp. 71-86, 1996.
S.A. Broitman, et al., "Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic `metastases` in vivo," Dietary Phytochemicals in Cancer Prevention and Treatment, American Institute for Cancer Research, Plenum Press, New York, pp. 111-130, 1996.
K.K. Carroll, et al., "In vitro inhibition of proliferation of MDA-MB-45 human breast cancer cells by combinations of tocotrienols and flavonoids," FASEB J. 9:A868, 1995 (Abstract).
G.L. Case, et al., "Induction of geranyl pyrophosphate pyrophosphatase activity by cholesterol-suppressive isoprenoids," Lipids 30(4):357-359, 1995.
C.E. Elson and S.G. Yu, "The chemoprevention of cancer by mevalonate-derived contituents of fruits and vegetables," Am. Ins. Nutr. pp. 607-614, 1994.
C.E. Elson, "Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease," Am. Ins. Nutr. pp. 1666S-1672S, 1995.
C.E. Elson and A.A. Qureshi, "Coupling the cholesterol- and tumor-suppressive actions of palm oil to the impact of its minor constituents on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity," Prostagland. Leukot. Essen. Fat. Acids 52:205-208, 1995.
C.E. Elson, et al., "Functional consequences of the modulation of 3-hydroxy-3-methylglutaryl coenzyme A.sup.1 reductase by isoprenoids," Mar. 28-Apr. 1, 1998 (AACR Abstract).
S.H. Goh, et al., "Inhibition of tumour promotion by various palm-oil tocotrienols," Int. J. Cancer 57:529-531, 1994.
M.N. Gould, et al., "A comparison of tocopherol and tocotrienol of the chemoprevention of chemically induced rat mammary tumors," Am. J. Nutr. 53:1068S-1070S, 1991.
N. Guthrie, et al., "Inhibition of proliferation of MDA-MB-435 human breast cancer cells by individual tocotrienols from palm oil," AACR Proc. 35:629, 1994 (Abstract).
N. Guthrie, et al., "In vitro inhibition of proliferation of receptor-positive MCF-7 human breast cancer cells by palm oil tocotrienols," FASEB J. 9:A988, 1995 (Abstract).
N. Guthrie, et al., "Effect of palm oil tocotrienols on the proliferation of ras-transformed NIH-3T3 cells and on farnesyl: and geranylgeranyl:protein transferase activity," FASEB J. 10:A559, 1996 (Abstract).
N. Guthrie, et al., "Combined effects of palm oil tocotrienols, flavonoids and tamoxifen on the proliferation of estrogen receptor-positive MCF-7 human breast cancer cells," AACR Proc. 37:280, 1996 (Abstract).
L. He, et al., "Isoprenoids suppress the growth of musine B16 melanomas in vitro and in vivo," Biochem. Mol. Roles Nutr. pp. 001-007, 1996.
J.P. Jani, et al., "Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis," Invas. Metas. 13:314-324, 1993.
K. Komiyama, et al., "Studies on the biological activity of tocotrienols," Chem. Pharm. Bull. 37(5):1369-1371, 1989.
H. Mo, et al., "End products of plant mevalonate pathways induce apoptosis in tumor cells," (Abstract).
H. Mo, et al., "IC.sub.50 values for the suppression of B16 melanoma cell proliferation by monoterpenoids derivatives," Apr. 18-22, 1998 (ExpBiol 98 Abstract).
K. Nesaretnam, et al., "Effect of tocotrienols on the growth of a human breast cancer cell line in culture," Lipids 30(12):1139-1143. 1995.
R.A. Parker, et al., "Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase," J. Biol. Chem. 268(15):11230-11238, 1993.
B.C. Pearce, et al., "Hypocholesterolemic activity of synthetic and natural tocotrienols," J. Med. Chem. 35(20):3595-3606, 1992.
B.C. Pearce, et al., "Inhibitors of cholesterol biosynthesis. 2. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols," J. Med. Chem. 37(4):526-541, 1994.
A.A. Qureshi, et al., "Response of hypercholesterolemic subjects to administration of tocotrienols," Lipids 30(12):1171-1177, 1995.
A.A. Qureshi, et al., "N24: The combined therapy of lovastatin and tocotrienols (palmvitee) in hypercholesterolemic human subjects," Proceedings of the 1996 PORIM International Palm Oil Congress (Nutrition) pp. 168-180, 1996.
B. Tan, "Antitumor effects of palm carotenes and tocotrienols in HRS/J hairless female mice," Nut. Res. 12(1):S163-S173, 1992.
A. Thibault, et al., "Phase I study of lovastatin an inhibitor of the mevalonate pathway, in patients with cancer," Clin. Can. Res. 2:483-491, 1996.
S.G. Yu, et al., "Dietary .beta.-ionone suppresses hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity," J. Agric. Food Chem. 42(7):1493-1496, 1994.
S.G. Yu, et al., "Efficacy of .beta.-ionone in the chemoprevention of rat mammary carcinogenesis," J. Agric. Food Chem. 43(8):214-2147, 1995.
W. Zurinah, et al., "Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats," Am. J. Clin. Nutr. 53:1076S-1081S, 1991.
C.E. Elson, "Cholesterol-suppressive and anticarcinogenic actions of anutrient, isoprenoid-derived constituents of food," J. Opt. Nut. 1:16-20, 1992.
C.E. Elson, "The Impact of Palm Oil on Experimental Carcinogenesis," In Vitamin E in Health and Disease, ed. L. Packer and J. Fuchs, Marcel Dekker, Inc., New York, pp. 533-545, 1993.
C.E. Elson, "Dietary fat and cancer: Anomalous responses to dietary palm oil," Perspectives, A Quarterly Report on New Developments in Fats and Oils Nutrition & Health, pp. 1-4, 1993.
C.E. Elson and S.G. Yu, "Coupling the cholesterol- and tumor-suppressive actions of palm oil to the impact of its minor constituents on mevalonate synthesis," Perspectives, A Periodic Report on New Developments in Fats and Oils Nutrition & Health, p. 1, 1994.
C.E. Elson, "Dietary Fat and Cardiovascular Disease: Anomalous responses to palm oil," Perspectives, A Periodic Report on New Developments in Fats and Oils Nutrition & Health, p. 1, 1994.
C.E. Elson, et al., "The cholesterol- and tumor-suppressive actions of palm oil isoprenoids," Nutrition, Lipids, Health and Disease, Ong, A.S.H., et al., AOCS Press, Champaign, IL, pp. 109-116, 1995.
C.E. Elson, "Dietary fat and cardiovascular disease: Anomalous responses to palm oil," Malaysian Oil Sci. & Tech. 4:18-22, 1995.
N. Guthrie, et al., "N15: Palm oil tocotrienols and plant flavonoids act synergistically with each other and with tamoxifen inhibiting proliferation and growth of estrogen-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells in culture," Proceedings of the 1996 PORIM International Palm Oil Congress (Nutrition), pp. 90-99, 1996.
M. Jung, et al., "Synthesis and biological activity of .beta.-ionone-derived alcohols for cancer chemoprevention," Anticancer Res. 18:189-192, 1998.
K. Nesaretnam, et al., "Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status," Lipids 33(5):461-469, 1998.
Goldberg Jerome D.
Wisconsin Alumni Research Foundation
LandOfFree
Method of suppressing tumor growth with combinations of isopreno does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of suppressing tumor growth with combinations of isopreno, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of suppressing tumor growth with combinations of isopreno will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-469597