Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-14
1992-12-08
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514909, A61K 31435
Patent
active
051698528
ABSTRACT:
Compounds of formula I are useful for suppressing appetite, and for altering macronutrient preferences, ##STR1## where the R.sub.2 -R.sub.9 substituents are so selected as to meet a defined quantitative structure activity relationship (QSAR) quantity relating to the partition coefficient of the compound, the net charge on the ring nitrogen, and the radical superfdelocalizability at the position-8 ring carbon.
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Adriaenssens Peter I.
Barchas Jack D.
Bitner Robert S.
Bowersox Stephen S.
Elliott Glen R.
Bond Robert T.
Dehlinger Peter J.
Neurex Corporation
Stratford Carol A.
Ward E. C.
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