Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2006-12-05
2006-12-05
Nashed, Nashaat T. (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C530S350000, C530S412000, C530S418000
Reexamination Certificate
active
07144988
ABSTRACT:
Crystals comprising a modified interleukin-1 type 1 receptor (IL-1R1) and one or more modulators of IL-1 activity are described. Methods of identifying potential inhibitors of IL-1 activity are also described. Compositions and methods for the treatment of IL-1 mediated diseases, such as rheumatoid arthritis, osteoarthritis, and other inflammatory conditions, are described.
REFERENCES:
Vigers et al. X-ray crystal structure of small antagonist peptide bound to interleukin-1 receptor type 1. J. Biol. Chem. 275 (47), 36927-36933 (2000).
Vigers et al. Crystal structure of type-l interleukin-1 receptor complexed with interleukin-1beta. Nature 386, 190-194 (1997).
Schreuder et al. A new cytokine-receptor binding mode revealed by crystal structure of IL-1 receptor with antagonist. Nature, 386, 194-200 (1997).
Brandhuber Barbara J.
Vigers Guy P. A.
Array Biopharma Inc.
Nashed Nashaat T.
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