Method of strength enhancement of collagen constructs

Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues

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8 941, 81275, 623 11, A61L 1700, A63B 5102, D01C 300

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057180121

ABSTRACT:
A method for improving the tensile strength of wet collagen threads or collagen thread constructs for implantation to replace or repair tissue or organs wherein the strength of the threads is improved by plasticizing the threads with a plasticizing agent, imparting a tensile load to the collagen thread to strain the collagen thread; allowing the load in the thread to decrease by stress-relaxation or by creep conditioning methods and finally, removing the plasticizing agent. Prosthetic devices comprising collagen threads with improved strength characteristics are intended to repair load bearing tissues such as ligaments and tendons.

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