Method of storing red blood cells with an acidic additive...

Details Method of storing red blood cells with an acidic additive... Method of storing red blood cells with an acidic additive...

2005-05-13

2011-12-06

Saucier, Sandra (Department: 1657)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

Reexamination Certificate

active

08071282

ABSTRACT:
There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol, NaH2PO4, and optionally NaCl and/or NH4Cl. Composition are preferably used with oxygen-depletion refrigerated storage of red blood cells and may optionally be employed with nutrient supplements extending the useful shelf life of stored blood.

REFERENCES:
patent: 5624794 (1997-04-01), Bitensky et al.
patent: 5789151 (1998-08-01), Bitensky et al.
patent: WO 96/29864 (1996-10-01), None
Greenwalt et al., “Studies in Red Blood Cell Preservation”, Vox Sang. 65 : 87-94 (1993).
De Angelis et al., “Erythrocyte Shape Control in Stored Blood: The Effect of Additive Solution on Shape Recovery”, Haematologica 73: 7-12 (1988).
Hamasaki et al., “Acid Citrate Dextrose Phosphoenolpyruvate Medium as a Rejuvenant for Blood Storage”, Transfusion 23 (10) : 1-7 (1983).
Valeri et al., “The survival, function and hemolysis of human RBCs stored at 4C in additive solution (AS-1, AS-3 or AS-5) . . . ”, Transfusion 40 : 1341-45 (Nov. 2000).

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