Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1997-08-12
1998-11-03
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
424450, A61K 4904, A61K 9127
Patent
active
058304355
ABSTRACT:
Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.
REFERENCES:
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4347707 (1982-09-01), Zemelman et al.
patent: 5205287 (1993-04-01), Erbel et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5518709 (1996-05-01), Sutton et al.
patent: 5529766 (1996-06-01), Klaveness et al.
Journal of Liposome Research, pp. 861-874 (1994); Unger et al: "Gas Filled Lipid Bilayers as Imaging Contrast Agents".
Brochot Jean
Schneider Michel
Yan Feng
Bracco Research S.A.
Hartley Michael G.
Hollinden Gary E.
LandOfFree
Method of storing frozen microbubble suspensions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of storing frozen microbubble suspensions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of storing frozen microbubble suspensions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-686516