Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-05-11
1992-10-27
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 62, 514885, 536117, 536 187, 536 179, 435822, A61K 31715, A61K 3170, A61K 3900, C12N 100
Patent
active
051589397
ABSTRACT:
A method is disclosed for stimulating the immune systems of animals with non-toxic lipid A derivatives. The derivatives include the lipopolysaccharide (LPS) and diphosphoryl lipid A (DPLA) for Rhodopsuedomonas.
REFERENCES:
patent: 4746742 (1988-05-01), Hasegawa et al.
Strittmatter et al., "Nontoxi Lipopolysaccharide from Rhodopseudomonas sphaeroides ATC 17023," Journal of Bacteriology, Jul. 1983, pp. 153-158.
Cotter et al., "Structural Determination of Lipid A From Gram Negative Bacteria Using Laser Desorption Mass Spectrometry," Biomedical and Environmental Mass Spectormetry, vol. 14, pp. 591-598 (1987).
Takayama et al., "Diphosphoryl Lipid A from Rhodopseudomonas sphaeroides ATCC 17023 Blocks Induction of Cachectin in Macrophages by Lipopolysaccharide", Infection and Immunity, Apr. 1989, pp. 1336-1338.
Qureshi et al., 1988, The Journal of Biological Chemistry, "Location of Fatty Acids in Lipid A Obtained from Lipopolysaccharide of Rhodopseudomonas sphaeroides ATCC 17023," pp. 5502-5504.
Krauss et al. 1989, Eur. J. Biochem. 180, 519-526, "Structural Analysis of the nontoxic lipid A of Rhodobacter capsulatus 37b4".
Qureshi Nilofer
Takayama Kuni K.
Brown Johnnie R.
White Everett
Wisconsin Alumni Research Foundation
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