Method of stimulating the immune system

Details Method of stimulating the immune system Method of stimulating the immune system

1991-06-12

1993-08-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514885, A61K 3174

Patent

active

052346838

ABSTRACT:
The present invention relates to biologically-active copolymers and to compounds that can be safely used to cause the thymus of an animal or human to increase in size, thereby replenishing the T-lymphocyte population. When injected into an animal or human with an antigen, certain of the biologically-active copolymers cause immunosuppression to the antigen.
When injected into poultry, certain of the biologically-active copolymers modulate immune responsiveness. The biologically active copolymers are also useful as growth promoters for animals. Compounds within the biologically-active copolymers of the present invention are effective tumoricidal agents. At low concentration, certain of the biologically-active copolymers can cause dedifferentiated cells to differentiate.
The biologically-active copolymer of the present invention is a safe and non-toxic formulation that can effectively be administered to animals or humans. The biologically-active copolymer can be mixed in an oil and water emulsion and administered to an animal or human by injection or by oral administration.

REFERENCES:
patent: 3740421 (1973-06-01), Schmolka
patent: 4407790 (1983-10-01), Oakes et al.
Schmolka I., "A Review of Block Polymer Surfactants", J. Am. Chem. Socy., vol. 54, No. 3, pp. 110-116 (1977).
Ceresa, R. J. Editor, "The Applications of Block Copolymer Polyol Surfactants", Block and Graft Copolymerization vol. 2, pp. 174-272, (1976).
Hunter et al. "The Adjuvant Activity of Nonionic Block Polymer Surfactants," The Journal of Immunology, 127:3 pp. 1244-1250 (1981).

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