Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-04-29
1996-12-24
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524021, 4352403, 43524031, 43524025, C12N 500, C12N 502
Patent
active
055873090
ABSTRACT:
A method of inducing the proliferation and/or differentiation of human fetal pancreatic cells entails contacting such cells in primary culture with Hepatocyte Growth Factor/Scatter Factor, thereby inducing a proliferation of .beta.-epithelial cells, an increase in the number of .beta.-epithelial cells which form islet-like cell clusters, and an increase in insulin production per cell. The method provides increased numbers of functional islet-like cell clusters for transplantation, for example, into Type 1 diabetic patients. The method can be scaled up so as to provide clinically useful numbers of cells for transplantation.
REFERENCES:
patent: 5362716 (1994-11-01), Kmiecik et al.
Rubin et al. "Hepatocyte Growth Factor/Scatter . . . ", Biophysica Acta, 1155:357-71; 1993.
Strain "Hepatocyte Growth Factor: Another Ubiquitous Cytokine", J. Endocrin., 137:1-5, 1993.
Andersson et al. "Fetal Pancreatic Transplantation", Transplantation Review, 6:1, 20-38, Jan. 1992.
Bhargava et al. "Scatter Factor and Hepatocyte Growth Factor . . . ", Cell Growth & Different., 3:11-20, Jan. 1992.
Defrances et al. "The Presence of Hepatocyte Growth Factor . . . ", Development, 116:387-95, 1992.
Furlong "The Biology of Hepatocyte Growth Factor/Scatter Factor", Bioessays, 14:9, 613-17, Sep. 1992.
Swenne "Pancreatic Beta-Cell Growth and Diabetes Mellitus", Diabetologia, 35: 193-201, 1992.
Tsuda et al. "Immunohistochemical Localization of Hepatocyte . . . ", Jpn. J. Cancer Res., 83:1262-66, Dec. 1992.
Hollerstrom et al. "Functional Maturation and Proliferation . . . ", Diabetes, 40:2, 89-93, Dec. 1991.
Weidner et al. "Evidence for the Identity of Human Scatter Factor . . . ", Proc. Natl. Acad. Sci., 88:7001-05, Aug. 1991.
Gherardi et al. "Hepatocyte Growth Factor-Scatter . . . ", Commentary, Cancer Cells, 3:6, 227-32, Jun. 1991.
Wolf et al. "Localization of Hepatocyte Growth Factor In Human and Rat . . . ", Hepatology, 14:3, 488-94, May 1991.
Kan et al. "Hepatocyte Growth Factor/Hepatopoietin . . . ", Biochem. & Biophy. Res. Comm., 174:1, 331-37, Jan. 1991.
Furlong et al. "Comparison of Biological and Immunochemical Properties . . . ", J. Cell Sci., 100:173-77, 1991.
Nakamura "Structure and Function of Hepatocyte Growth Factor", Prog. In Growth Factor Res., 3:67-85, 1991.
Gherardi et al. "Hepatocytes and Scatter Factor", Nature, 346:228, Jul. 1990.
Tashiro et al. "Deduced Primary Structure of Rat Hepatocyte . . . ", Proc.Natl. Acad. Sci., 87:3200-04, Apr. 1990.
Kinoshita et al. "Marked Increase of HGF mRNA . . . ", Biochem. & Biophys. Res. Comm., 165:3, 1229-34, Dec. 1989.
Nakamura et al. "Molecular Cloning and Expression . . . ", Letters of Nature, 342:440-43, Nov. 1989.
Miyazawa, et al. "Molecular Cloning and Sequence Analysis . . . ", Biochem. & Biophys. Res. Comm., 163:2, 967-73, Sep. 1989.
Gohda et al. "Purification and Partial Characterization . . . ", J. Clin. Invest., 81:414-19, Feb. 1988.
Vinik et al, Endocrinology & Metabolism Clinics of North America, vol. 22. No. 4 (Dec. 1993) pp. 875-887.
Moghul et al., Proceedings of the American Assoc. for Cancer Research, 35:125 (Mar. 1994).
Dunger et al., Hormone Metab. Res., 23:201-204 (1991).
Beattie et al., J. Clinical Endocrinology & Metabolism, 73(1):93-98 (1991).
Nielsen, J. H. ACTA Endocrino Logica, Suppl 266:7-39 (1985).
Hulinsky, Transplantation Proceedings, 24 (6):2819 (Dec. 1992).
Adamson et al, The Canadian J. of Chemical Engineering, 64:531-539 (Aug. 1986).
Otonkoski et al, Cell Transplantation, 3(3):218 (Apr. 7, 1994).
Calvo et al., Pancreas 8(6):751 (1993).
Beattie Gillian M.
Hayek Alberto
Otonkoski Timo P. J.
Rubin Jeffrey
Dadio Susan M.
The United States of America as represented by the Department of
Whittler Institute for Diabetes and Endocrinology
Wityshyn Michael G.
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