Method of stimulating myelination of cells

Details Method of stimulating myelination of cells Method of stimulating myelination of cells

1990-06-21

1993-06-15

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, A61K 3702, C07K 706, C07K 708

Patent

active

052198375

ABSTRACT:
The present invention provides methods for treating mammalian diseases and conditions characterized by myelin destruction. The present invention provides methods for inducing myelin formation by myelin forming cells expressing reovirus type 3 receptors comprising administering to such cells an effective amount of a compound bindable with the reovirus type 3 receptor. The compounds for use in the method of the invention preferably comprise antibodies and peptides, more preferably synthetic peptides.

REFERENCES:
patent: 4230696 (1980-10-01), Hashim
patent: 4615884 (1986-10-01), Harshman
patent: 5003044 (1991-03-01), Hunter et al.
Ventimiglia, R., et al., Proc. Natl. Acad. Sci. USA 84:5073-5077 (1987).

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