Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1996-03-15
2000-03-07
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241881, 4241871, 4242071, A61K 3921
Patent
active
060336722
ABSTRACT:
The present invention provides a vaccine comprising a caprine arthritis-encephalitis virus (CAEV) immunogen and a pharmaceutically acceptable carrier. The invention also provides a method of stimulating an immune response in an individual against human immunodeficiency virus-1 infection or against CAEV infection by administering a therapeutically effective amount of a CAEV immunogen to the individual. The invention further provides a method of stimulating an immune response in vitro by contacting a lymphocyte with a therapeutically effective amount of a CAEV immunogen.
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Webster's II New Riverside University Dictionary: pp. 626 and 1200, 1994.
Knowles, et al.: Structure and genentic variability of envelope glycoproteins of two antigenic variants of Caprine Arthritis-Encephalitis Lentivirus: J. of Virology: vol. 65 No. 11: pp. 5744-5750, 1991.
Cheevers, et al.: Caprine arthritis-encephalitis lentivirus (CAEV) challenge of goats immunized with recombinant vaccinia virus expressing CAEV surface and transmembrane envelope glycoproteins: Vet. Immunology and Immunopathology: 42: pp. 237-251, 1994.
Serruya, et al: Identification of novel CAEC-like lentivirus . . . : AIDS Res. and Hum. Retrovir.: vol. 10 S. 1; PS54, 1994.
Douvas, et al.: Cross-reactivity between autoimmune anti-U1 snRNP . . . : AIDS Res. and Hum. Retrovir.: V. 10 No.3: pp. 253-262, 1994.
Douvas, A., et al., 1997, "Human-infecting forms of caprine arthritis-encephalitis virus (CAEV) in HIV vaccine strategies.", Conf. Adv. AIDS Vaccine Dev. pp. 65.
Bertoni, G., et al., 1994, "Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis.", J. Virol. 68(11):7139-47, abstract provided.
Douvas Angeline
Ehresmann Glenn
Parkin J. S.
Scheiner Laurie
Shuster Michael J.
University of Southern California
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