Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-08-23
2011-08-23
Angell, Jon E (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
Reexamination Certificate
active
08003619
ABSTRACT:
This invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals.
REFERENCES:
patent: 5366878 (1994-11-01), Pederson et al.
patent: 5635377 (1997-06-01), Pederson et al.
patent: 5652355 (1997-07-01), Metelev et al.
patent: 6143881 (2000-11-01), Metelev et al.
patent: 6180613 (2001-01-01), Kaplitt et al.
patent: 6235310 (2001-05-01), Wang et al.
patent: 6346614 (2002-02-01), Metelev et al.
patent: 6586524 (2003-07-01), Sagara
patent: 2001/0007666 (2001-07-01), Hoffman et al.
patent: 2003/0077829 (2003-04-01), MacLachlan
patent: 2003/0130186 (2003-07-01), Vargeese et al.
patent: 2004/0180848 (2004-09-01), Fesik et al.
patent: 2004/0259097 (2004-12-01), De Backer et al.
patent: 2005/0159376 (2005-07-01), McSwiggen et al.
patent: WO 96/10390 (1996-04-01), None
patent: WO 96/10391 (1996-04-01), None
patent: WO 96/10392 (1996-04-01), None
patent: WO 00/03683 (2000-01-01), None
patent: WO-01/93902 (2001-12-01), None
patent: WO 2005/087541 (2002-11-01), None
patent: WO-03/070910 (2003-08-01), None
patent: WO-03/070918 (2003-08-01), None
patent: WO-03/074654 (2003-09-01), None
patent: WO-2004/004743 (2004-01-01), None
patent: WO 2004/013280 (2004-02-01), None
patent: WO-2004/036621 (2004-04-01), None
patent: WO-2004/090134 (2004-10-01), None
Caplen et al. Ann. N. Y. Acad. Sci. 2003, 1002:56-62.
Kuramoto et al. (Jpn. J. Cancer Res. 1992, vol. 83, pp. 1128-1131).
Ahlquist et al., “RNA-Dependent RNA polymerases, Viruses, and RNA Silencing,”Science296: 1270-1273 (2002).
Alexopoulou et al., “Recognition of Double-Stranded RNA and Activation of NF-κB by Toll-Like Receptor 3,”Nature413: 732-738 (2001).
Asselin-Paturel et al., “Mouse Type I IFN-Producing Cells are Immature APC's with Plasmacytoid Morphology,”Nat. Immunol. 2: 1144-50 (2001).
Baenziger, J. And Fiete, D., “Galactose and N-Acetylgalactosamine-Specific Endocytosis of Glycopeptides by Isolated Rat Hepatocytes,”Cell22:611-620 (1980).
Bannai et al., “Effect of Injection of Antisense Oligodeoxynucleotides of GAD Isozymes into Rat Ventromedial Hypothalamus on Food Intake and Locomotor Activity,”Brain Research784: 305-315 (1998).
Bannai et al., “Water-Absorbent Polymer as a Carrier for a Discrete Deposit of Antisense Oligodeoxynucleotides in the Central Nervous System,”Brain Research3: 83-87 (1998).
Bauer et al., “Human TLR9 Confers Responsiveness to Bacterial DNA via Species-Specific CpG Motif Recognition,”PNAS98: 9237-9242 (2001).
Bettinger et al., “Size Reduction of Galactosylated PEI/DNA Complexes Imporives Lectin-Mediated Gene Transfer into Hepatocytes,”Bioconjugate Chem. 10: 558-561 (1990).
Bitko et al. “Phenotypic Silencing of Cytoplasmic Genes Using Sequence-Specific Double-Stranded Short Interfereing RNA and Its Application in the Reverse Genetics of Wild Type Negative-Strand RNA Viruses”BMC Microbiology1: 1-11 (2001).
Bridge et al. “Induction of an Interferon Response by RNAi Vectors in Mammalian Cells”Nature Genetics34(3): 263-264 (2003).
Broaddus et al., “Distribution and Stability of Antisense Phosphorothioate Oligonucleotides in Rodent Brain Following Direct Intraparenchymal Controlled-Rate Infusion,”J Neurosurg. 88: 734-742 (1998).
Choi et al. “Effect of Poly(ethylene glycol) Grafting on Polyethylenimine as a Gene Transfer Vector in vitro”Bull. Korean Chem. Soc. 22(1): 46-52 (2001).
Connolly et al. “Binding and Endocytosis of Cluster Glycosides by Rabbit Hepatocytes”The Journal of Biological Chemistry257(2): 939-945 (1982).
Davidson, B., “Hepatic Diseases—Hitting the Target with Inhibitory RNAs,” The Nw England Journal of Medicine, 349: 2357-2359 (2003).
Diebold et al. “Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA”Science, 303: 1529-1531 (2004).
Diebold et al. “Mannose Polyethylenimine Conjugates for Targeted DNA Delivery into Dendritic Cells”The Journal of Biological Chemistry, 274(27): 19087-19094 (1999).
Dittmer et al., “Treatement of Infectious Diseases with Immunostimulatory Oligodeoxynucleotides Containing CpG Motifs,”Current Opinion in Microbiology6: 472-477 (2003).
Edwards et al., “Toll-Like Receptor Expression in Murine DG Subsets: Lack of TLR7 Expresion by CD8α+DC Correlates with Unresponsiveness to Imidazoquinolines,”Eur. J. Immunol. 33: 827-833 (2003).
Elbashir et al. “Duplexes of 21-Nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells”Nature, 411: 494-498 (2001).
Elbashir et al. “RNA Interference is Mediated by 21- and 22-Nucleotide RNAs”Genes&Development, 15: 188-200 (2001).
Elbashir et al. “Functional Anatomy of siRNAs for Mediating Efficient RNAi inDrosphila melanogasterEmbryo Lysate”The EMBO Journal20(23): 6877-6888 (2001).
Furgeson et al., “Modified Linear Polyethylenimine-Cholesterol Conjugates for DNA Complexation,”Bioconjugate Chem. 14: 840-847 (2003).
Godbey et al., “Poly(ethylenimine) and its Role in Gene Delivery,” Journal of Controlled Release 60: 149-160 (1999).
Godbey et al. Tracking the Intracellular Path of Poly(ethylenimine)/DNA Complexes for Gene Delivery:Proc. Natl. Acad. Sci. USA96: 5177-5181 (1999).
Haley, B. And Zamore, P., “Kinetic Analysis of the RNAi Enzyme Complex,”Nature Structural&Molecular Biology11(7): 599-606 (2004).
Halpern et al., “Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α,”Cellular Immunology167:72-78 (1996).
Hammond et al. “An RNA-Directed Nuclease Mediates Post-Transcriptional Gene Silencing inDrosphilaCells”Nature404: 293-296(2000).
Hannon, G., “RNA Interference,”Nature418: 244-251 (2002).
Hartmann et al. “Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses in Vitro and in Vivo”The Journal of Immunology, pp. 1617-1624 (2000).
Hartmann et al. “Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells”The Journal of Immunology, pp. 944-953 (2000).
Heckelsmiller et al., “Combined Dendritic Cell- and CpG Oligonucleotide-Based Immune Therapy Curses Large Murine Tumors that Resist Chemotherapy,”Eur. J. Immunol. 32: 3235-3245 (2002).
Heckelsmiller et al. “Peritumoral CpG DNA Elicits a Coordinated Response of CD8 T Cells and Innate Effectors to Cure Established Tumors in a Murine Colon Carcinoma Model”The Journal of Immunology, pp. 3892-3899 (2002).
Heidel et al. “Lack of Interferon Response in Animals to Nakes siRNAs”Nature Biotechnology22(12): 1579-1582 (2004).
Heil et al. “Species-Specific Recognition of Single-Stranded RNA via Toll-like 7 and 8”Science, 303: 1526-1529 (2004).
Heil et al., “The Toll-Like Receptor 4 (TLR7)-Specific Stim,ulus Loxoribine Uncovers a Strong Relationship within the TLR7, 8 and 9 Subfamily,”Eur. J. Immunol. 33: 2987-2997 (2003).
Hoebe et al. “Upregulation of Costimulatory Molecules Induced by Lipopolysaccharide and Double-Stranded RNA Occurs by Trif-Dependent and Trif-Independent Pathways”Nature Immunology, 4(12): 1223-1229(2003).
Hornung et al. “Quantitative Expression of Toll-Like Receptor 1-10 mRNA in Cellular Subsets of Human Peripheral Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides”The Journal of Immunology, pp. 4532-4537, (2002).
Ishiwata et al. “Physical-Chemistry Characteristics and Biodistribution of Poly(ethylene glycol)-Coated Liposomes Using Ploy(oxyethylene) Cholesteryl Ether”Chemical and Pharmaceutical Bulletin, 43(6): 1005-1011 (1995).
Jackson et al., “Expression Profiling Reveals Off-Target Gene Regulation by RNAi,”Nature Biotechnology32(6): 63
de Fougerolles Antonin
Endres Stefan
Hartmann Gunther
Hornung Veit
Alnylam Pharmaceuticals, Inc.
Angell Jon E
Fenwick & West LLP
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