Method of stably radiolabeling antibodies with technetium and rh

Details Method of stably radiolabeling antibodies with technetium and rh Method of stably radiolabeling antibodies with technetium and rh

1984-05-03

1987-03-24

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4300, A61K 4900

Patent

active

046524401

ABSTRACT:
.sup.99 m Tc-labeling of antibodies and antibody fragments, either unconjugated or conjugated to DTPA, is effected in the presence of molar excess of free or carrier-bound DTPA to substantially completely inhibit direct technetium binding to non-stable binding sites on the antibody. The resultant .sup.99m Tc-labeled antibody has a stable label and is useful for, inter alia, tumor imaging by gamma scintigraphy and/or tumor therapy. Rhenium-labeling can be similarly effected.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4421735 (1983-12-01), Haber et al.
patent: 4478815 (1984-10-01), Burchiel et al.
Steigman et al, Int. J. Appl. Rad. Isotopes, 26 (1975) 601-609.
Khaw et al, J. Nucl. Med, 23 (1982) 1011-1019.
Hnatowich et al, Int. J. Appl. Rad. Isotopes, 33 (1982) 327-332.
Hnatowich et al, J. Immunol. Meth., 65 (1983) 147-157.

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