Method of stabilizing proteins

Details Method of stabilizing proteins Method of stabilizing proteins

2005-05-27

2010-12-28

Saoud, Christine J (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

C530S351000, C424S085100

Reexamination Certificate

active

07858082

ABSTRACT:
A method of preparing a stabilized bulk solution of a monomeric protein is described, which consists in providing a bulk of monomeric protein in a buffer solution and adding an excipient to the bulk, wherein the excipient is selected from the group consisting of bacteriostatic agents, surfactants, isotonicity agents, amino acids, antioxidants and combinations thereof. Prefereably the monomeric protein is IFN-beta.

REFERENCES:
patent: 4432895 (1984-02-01), Tarnowski
patent: 4588585 (1986-05-01), Mark et al.
patent: 4695623 (1987-09-01), Stabinsky
patent: 4737462 (1988-04-01), Mark et al.
patent: 4879111 (1989-11-01), Chong
patent: 4897471 (1990-01-01), Stabinsky
patent: 4904584 (1990-02-01), Shaw
patent: 4959314 (1990-09-01), Mark et al.
patent: 4965195 (1990-10-01), Namen et al.
patent: 5017691 (1991-05-01), Lee et al.
patent: 5116943 (1992-05-01), Koths et al.
patent: 5541293 (1996-07-01), Stabinsky
patent: 5917021 (1999-06-01), Lee
patent: 6013253 (2000-01-01), Martin et al.
patent: 2002/0172661 (2002-11-01), Shirley et al.
patent: 0736303 (1996-03-01), None
patent: WO98/28007 (1998-07-01), None
patent: WO 99/55377 (1999-11-01), None
patent: WO 03/002152 (2003-01-01), None
patent: WO 2004/096263 (2004-11-01), None
Derynck, R. et al. “Isolation and Structure of a Human Fibroblast Interferon Gene”,Nature, Jun. 19, 1980, pp. 542-547, vol. 285.
Rubinstein, S. et al. “Convenient Assay for Interferons”,Journal of Virology, Feb. 1981, pp. 755-758, vol. 37, No. 2.
Familletti, P. C. et al. “A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon”,Methods in Enzymology, 1981, pp. 387-394, vol. 78.
Shepard, H. M. et al. “A Single Amino Acid Change in IFN-β1Abolishes its Antiviral Activity”,Nature, Dec. 10, 1981, pp. 563-565, vol. 294.
Mark, D. F. et al. “Site-Specific Mutagenesis of the Human Fibroblast Interferon Gene”,Proc. Natl. Acad. Sci., Sep. 1984, pp. 5662-5666, vol. 81, No. 18.
Pestka, S. “Interferon Standards and General Abbreviations”,Methods in Enzymology, 1986, pp. 14-23, vol. 119.
Lam, X. M. et al. “The Effect of Benzyl Alcohol on Recombinant Human Interferon-γ”,Pharmaceutical Research, 1997, pp. 725-729, vol. 14, No. 6.
Schuck, P. “Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling”,Biophysical Journal, Mar. 2000, pp. 1606-1619, vol. 78.
Wang, W. “Instability, Stabilization, and Formulation of Liquid Protein Pharmaceuticals”,International Journal of Pharmaceutics, 1999, pp. 129-188, vol. 185.
Wang, Y.-C. J. et al. “Parenteral Formulations of Proteins and Peptides: Stability and Stabilizers”,Journal of Parenteral Science&Technology, 1988, pp. S4-S26, vol. 42.

Affiliated with

Also associated with

Rating

Method of stabilizing proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of stabilizing proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of stabilizing proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4221952