Method of stabilizing preparations for contact lenses

Details Method of stabilizing preparations for contact lenses Method of stabilizing preparations for contact lenses

1994-10-03

1996-11-05

Reamer, James H.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

514423, 514839, 514840, 422 28, A61K 3318

Patent

active

055715044

ABSTRACT:
With a specific aim to preventing the proteolytic enzyme in a preparation for contact lenses containing a proteolytic enzyme from deterioration in the state of aqueous solution, the present invention provides (1) a method of stabilizing a preparation for contact lenses containing a proteolytic enzyme, which comprises formulating the said preparation with a pyrrolidone compound, (2) a process for producing a prepration for contact lenses and (3) a preparation for contact lenses.
The preparation according to the present invention can be processed into the liquid or solid preparation form, wherein the liquid preparation can be processed into a one-component type preparation. The liquid preparation as well as the solid preparation, even after being dissolved in water, can maintain the activity of the proteolytic enzyme over a prolonged period of time, and can be used effectively for cleansing and cleaning, preservation and sterilization of contact lenses.

REFERENCES:
patent: 4863952 (1989-09-01), Abe et al.
patent: 4976969 (1990-12-01), Plamondon
patent: 5171526 (1992-12-01), Wong et al.
patent: 5322667 (1994-06-01), Sherwood
patent: 5352695 (1994-10-01), N'Guyen et al.
patent: 5411598 (1995-05-01), Tsao et al.
JP-A-5179291, Derwent Publications Ltd., Jul. 20, 1993.
Copy of European Search Report dated Feb. 21, 1996.

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