Method of stabilizing microtubules

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424 7808, 424 7832, 4352402, 436501, 436548, 436811, 549510, A61K 31335, A01N 4302

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active

055808980

ABSTRACT:
A method of stabilizing microtubules which are destabilized due to insufficient levels of normal human tau protein is disclosed. The method comprises the steps of contacting a microtubule that is destablizing due to a deficiency in normal tau protein with an amount of taxol sufficient to stabilize microtubules.

REFERENCES:
patent: 5362831 (1994-11-01), Mongelli et al.
patent: 5380751 (1995-01-01), Chen et al.
Everitte-Voegelein et al "J. Nat Prod" vol. 50 No. 1 Jan.-Feb. 1987 Taxol & Derivatives: A Biogenetic Hypothesis pp. 9-18.
Bramblett et al., "Regions with Abundant Neurofibrillary Pathology in Human Brain Exhibit a Selective Reduction in Levels of Binding-Competent .tau. and Accumulation of Abnormal .tau.-Isoforms (A68 Proteins)" Lab Invest. 66 212-222, (1992).
Bramblett et al. "The Abnormal Phosphorylation of Tau at Ser.sup.396 in Alzheimer's Disease Recpaitulates Phosphorylation During Development and Contributes to Reduced Microtubule Binding", Neuron 10: 1089-1099 (1993).
Butner and Kirschner, "Tau Protein Binds to Microtubules Through a Flexible Array of Distributed Weak Sites", J. Cell Biol 115: 717-730 (1991).
Drechsel et al., "Modulation of the Dynamic Instability of Tubulin Assembly by the Microtubule-Associated Protein Tau", Mol. Biol. Cell. 3: 1141-1154 (1992).
Goedert et al., "Expression of Separate Isoforms of Human Tau Protein: Correlation with the Tau Pattern in Brain and Effects on Tubulin Polymerization", Embo J. 9: 4225-4230 (1990).
Kosik et al., "Developmentally Regulated Expression of Specific Tau Sequences", Neuron 2: 1389-1387 (1989).
Lee et al., "Tau Proteins are Abnormally Expressed in Olfactory Epithelium of Alzheimer Patients and Developmentally Regulated in Human Fetal Spinal Cord", Experimental Neurology 121: 93-105 (1993).
Lindwall et al., "Phosphorylation Affects the Ability of Tau Protein to Promote Microtubule Assembly", J. Biol. Chem. 259: 5301-5305 (1984).
Murthy et al., "Microtubule Assembly Using the Microtubule-Associated Protein MAP-2 Prepared in Defined States of Phosphorylation with Protein Kinase and Phosphatase", Eur. J. Biochem. 137: 37-46 (1983).
Schiff et al. "Promotion of Microtubule Assembly in Vitro by Taxol", Nature 277: 665-667 (1979).
Trojanowski et al., "Altered Tau and Neurofiliament Proteins in NeuroDegenerative Diseases: Diagnostic Implications for Alzheimer's Disease and Lewy Body Dementias", Brain Pathol.3:45-54 (1993).
Vallee, "A Taxol-Dependent Procedure for the Isolation of Microtubles and Microtubule-Associated Proteins (MAPs)", J. Cell Biol. 92: 435-442 (1982).
Williams and Detrich, "Separation of Tubulin from Microtubule-Associated Proteins on Phosphocellulose. Accompanying Alterations in Concentrations of Buffer Components", Biochemistry 18: 2499-2503 (1979).

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