Method of stabilizing hyaluronidase with annexin II

Details Method of stabilizing hyaluronidase with annexin II Method of stabilizing hyaluronidase with annexin II

2006-10-03

2006-10-03

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

Reexamination Certificate

active

07115408

ABSTRACT:
This invention relates generally to the use of annexin II for the purpose of stabilizing a hyaluronidase enzyme for administration to the eyes of humans or other mammals.

REFERENCES:
patent: 2806815 (1957-09-01), Singher et al.
patent: 5866120 (1999-02-01), Karageozian et al.
Rich et al., “Accelerated clearance of experimental vitreous hemorrhage by Vitrase® : Relative roles of annexin II and hyaluronidase”, IOVS 41 (4) : S361 (Mar. 15, 2000).
Mochida et al. “Stability of purified hyaluronidase in aqueous solutions in the presence of several pssible protective agents”, Yakugaku Zasshi 80: 1173-6 (1960).

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