Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1992-07-07
1994-12-27
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 45, 424489, 514957, 514958, 514970, 5147723, A61K 914, A61K 4730
Patent
active
053763599
ABSTRACT:
A method of making a stabilized aerosol drug formulation is disclosed, along with the formulations so produced and metered drug inhalers containing the same. The method comprises combining a solid particulate drug composition with a fluoropolymer in a liquid fluorocarbon aerosol propellant to form a stable suspension. Further stabilization can be achieved by cooling the suspension for a time and to a temperature sufficient to adsorb the fluoropolymer to the solid particulate drug composition in the liquid fluorocarbon aerosol propellant. Preferred propellants for carrying out the invention are 1,1,1,2-tetrafluoroethane, heptafluoropropane, and mixtures thereof, and preferred fluoropolymers for carrying out the invention are fluoropolyethers.
REFERENCES:
patent: 4347236 (1982-08-01), Tanskanen
patent: 4352789 (1982-10-01), Thiel
patent: 4978389 (1990-12-01), Sato et al.
patent: 5118494 (1992-06-01), Schultz et al.
patent: 5126123 (1992-06-01), Johnson
Giovanni Pantini, Montefluos S.p.a. FOMBLIN HC Cosmetic Formulary.
Giovanni Pantini et al. Perfluoropolyethers For Cosmetics, in Drug and Cosmetic Industry (Sep. 1988).
Glaxo Inc.
Webman Edward J.
LandOfFree
Method of stabilizing aerosol formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of stabilizing aerosol formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of stabilizing aerosol formulations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-917263