Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-05-23
2000-08-15
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 91, 536 231, 536 235, 536 243, 536 2433, 536 253, 536 274, 935 77, 935 78, 935 16, 935 17, 935 18, 935 19, C12Q 168
Patent
active
061034630
ABSTRACT:
A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable segment. The constant segment of the immobilized oligonucleotides can be made complementary to the ends of strands obtained by digesting a double-stranded nucleic acid with a restriction enzyme and restoring the restriction sites, thereby permitting the sorting of strands according to their variable sequences adjacent to their constant terminal restored restriction sites.
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Veniaminova, A. G., Gorn, V. V., Zenkova, M. A., K
Chetverin Alexander B.
Kramer Fred Russell
Horlick Kenneth R.
Taylor Janell E.
The Public Health Research Institute of the City of New York, In
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