Method of solution overcoating with gelling polymer

Details Method of solution overcoating with gelling polymer Method of solution overcoating with gelling polymer

1996-09-20

1998-04-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424490, 424489, 424488, 424497, A61K 914

Patent

active

057388768

ABSTRACT:
The present invention generally relates to novel overcoating/encapsulation processes which are carried out in solution without the use of droplet generation devices. The processes may be used in the overcoating or encapsulation of a variety of materials, such as biological material, e.g., cells, proteins, etc., as well as pharmaceuticals. Compositions prepared using the methods of the present invention may find use in pharmaceutical formulation as well as coating biological material for a number of applications, including cell culturing and transplant therapy.

REFERENCES:
patent: 4164559 (1979-08-01), Miyata et al.
patent: 4177038 (1979-12-01), Biebricher et al.
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4407957 (1983-10-01), Lim
patent: 4409331 (1983-10-01), Lim
patent: 4543332 (1985-09-01), Jao et al.
patent: 4592098 (1986-06-01), Magnes
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4696286 (1987-09-01), Cochrum
patent: 4744933 (1988-05-01), Rha et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4789550 (1988-12-01), Hommel et al.
patent: 4791061 (1988-12-01), Sumino et al.
patent: 4798786 (1989-01-01), Tice et al.
patent: 4803168 (1989-02-01), Jarvis
patent: 4806355 (1989-02-01), Goosen et al.
patent: 4824916 (1989-04-01), Kerschner et al.
patent: 4902295 (1990-02-01), Walthall et al.
patent: 4922295 (1990-05-01), Walthall et al.
patent: 4956128 (1990-09-01), Hommel et al.
patent: 5041292 (1991-08-01), Feijen
patent: 5227298 (1993-07-01), Weber et al.
patent: 5262055 (1993-11-01), Bae et al.
patent: 5286495 (1994-02-01), Batich et al.
patent: 5334640 (1994-08-01), Desai et al.
patent: 5362478 (1994-11-01), Desai et al.
Sun and O'Shea, "Microencapsulation of Living Cells--Long-Term Delivery System," J. Controlled Release, 2:137-141 (1985).
Sun et al., "Microencapsulation of Living Cells--a Long-Term Delivery System," J. Controlled Release 2:137-141 (1985).
U.S. application No. 08/186,327 filed Jan. 24, 1994.
Abuchowski et al., "Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol," J. Biol. Chem. 252:3578-3581 (1977).
Brendel et al., "Improved functional survivial of human islets of langerhans in three-dimensional matrix culture," Cell Trans. 3:427-435 (1994).
Chao et al., "Entrapment of cultured pancreas islets in three-dimensional collagen matrices," Cell Transplantation 1:51-60 (1992).
Chiang et al., "Synthesis of ionic conducting interpenetrating polymer networks," Polymer Communications pp. 34-35 (Butterworth & Co.) 1987.
Chaikof et al., "Surface topography of crosslinked poly(ethylene oxide)/polysiloxane networks in the dry and hydrated states," Polymer Communications 31:182-185 (1990).
Corkhill et al., "Synthetic hydrogels: 7. High EWC semi-interpenetrating polymer networks based on cellulose esters and N-containing hydrophilic monomers," Polymer 31:1526-1537 (1990).
Goosen et al., Fundamentals of Animal Cell Encapsulation and Immobilization, Ch. 6, pp. 114-131; Ch. 8, pp. 190-193; Ch. 13, 302-307 (CRC Press (1993)).
Lim et al., "Microencapsulation of living cells and tissues," J. Pharm. Sci. 70:351-354 (1981).
Lim et al., "Microencapsulated islets as bioartificial endocrine pancreas," Science 210:908-910 (1981).
Lum et al., "Prolonged reversal of diabetic state in NOD mice by xenografts of microencapsulated rat islets," Diabetes 40:1511-1516 (1993).
Ohgawara et al., "Maintenance of embedded pig pancreatic pseudo-islets in a collagen gel matrix: study of the effect of hydrocortisone, a collagenase inhibitor, and nicotinamide on collagenolysis and the morphogenesis of pancreatic islet-cells in collagen gel matrix," In Vitro Cell. Dev. Biol. 26:348-352 (1990).

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